Alzhiermers Drugs

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NSAID Use

Prophylaxis -Long term use before symptoms arise may prevent or retard AD development.
NSAID MOA

Improves brain blood flow?
Statins Use

prophylaxis
Statins MOA

Reduces hypercholesterimia.
Antihypertensive Drugs Use

prophylaxis
Antihypertensive Drugs MOA

High bp in middle age correlates with increased AD incidence later.
Tacrine Use

For (minor) enhancement of neurotransmission and cognition in AD
Tacrine MOA

reversible cholinesterase inhibitor
Donepezil MOA

reversible cholinesterase inhibitor
Rivastigmine MOA

reversible cholinesterase inhibitor
Glantamine MOA

reversible cholinesterase inhibitor
Memantine MOA

reversible NMDAr antagonist
Tacrine Use

For (minor) enhancement of neurotransmission and cognition in AD
Donepezil Use

For (minor) enhancement of neurotransmission and cognition in AD.
Rivastigmine Use

For (minor) enhancement of neurotransmission and cognition in AD.
Glantamine Use

For (minor) enhancement of neurotransmission and cognition in AD.
Mematine Use

Additive benefit when used with reversible cholinesterase inhibitors.
Tacrine Adverse Effects

Cholinergic (SLUD)

Major Direct Hepatic Toxicity
Donepezil Adverse Effects

Cholinergic (SLUD)

No Direct Hepatic Toxicity

Yes hepatotoxic drug interactions
Rivastigmine Adverse Effects

Cholinergic (SLUD)

No Direct Hepatic Toxicity

No hepatotoxic drug interactions
Glantamine Adverse Effects

Cholinergic (SLUD)

No Direct Hepatic Toxicity

Yes hepatotoxic drug interactions
Tacrine Distinguishing Trait

1st reversible choinesterase inhibitor.

Not marketed anymore

non-selective

QID
Donepezil Distinguishing Characteristics

DOC for AD patients who are not on multidrug regimines.
Rivastigmine Distinguishing Traits

DOC for AD patients who ARE on multi-drug regimens.
Glantamine

Non selective.

Potentiates nicotinic Ach response too.

Author

krug0043

17414

Card Set

Alzhiermers Drugs

Description

Pharmacology II

Updated

2010-05-03T05:12:55Z

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