Dose Form Lab

Occupational Saftey and Health Administration

• the sensitivy of a balance
• the maximum change in load that will cause a specified change, one subdivision on the index plate, in the position of rest of the indicating element of the balance.

Prescription balance

6mg with no load and with a load of 10g on each pan

120g

15.5g

5% or greater

a method of measuring ingredients below the sensitivity of a scale by proportional dilution with inactive ingredient.

20 mg or 20 times 0.001g

level it using leveling screws...release arrest knob from locked position

NF national formulary

sensitivity requirement/ quantity desired

SR x 100/ permissible percent of error

• graduate cylinder
• pippettes
• droppers

a pipet and pipet filler

the apparant displacement of an object that follows a change in the position from which it is viewed, error of parallax could cause measuring errors larger than 5%

mixing ingredients of unequal quantities, where begins with the smallest qunatity and adds an equal quantity of the ingredient having a larger amount, process continues until all ingedients used

solid dosage forms in which the drug substances is enclosed in either a hard or soft soluble container of shell of a suitable form of gelatin.

• "dry-filled capsule"
• two sections,
• 1.longer end=body 2.slip on cap
• made of gelatin, FD&C colorants and sometimes opacifying agents titanium oxide.

000 largest to 5 smallest

• powder on paper not greater than 1/3 length of capsule
• body pressed repeatedly into the powder until filled
• cap replaced
• capsule weighed
• spatula helps push last quantity of material when packed

manual and automatic capsule filling machines can inscrease speed of filling operation