-
Quinidine Sulfate
- Class 1A anti-arrhythmic
- Blocks K channels
- Can cause QT prolongation
- Bad GI upset
-
Quinidine Gluconate
- Class 1A anti-arr
- Blocks K
- Less GI upset
-
Quinidine Polygalacturonate
same as gluconate
-
Procainamide/Pronestyl
- Class 1A
- Like taking 2 drugs, parent drug inhibits Na, metabolite inhibits K
- side effect = anti-nuclear antibody, Lupus like syndrome
-
Disopyramide/Norpace
- Class 1A
- Has very negative inotropic effects (weaken heart contraction)
- Only used in ICU
-
Lidocaine
- Class 1B
- Fairly long acting
- IV admin only
- Monitor for CNS effects!
-
Mexiletine
- Class 1B
- Ventricular arrhythmias only
- Generaly more toxic
-
Flecainide/Tambocor
- Class 1C
- Not used as much from increased mortality
-
Propafenone/Rythmol
- Class 1C
- Prodrug
- Metabolite has B blocker properties
-
Moricizin
- Class 1C
- Capable of inducing it own metabolism
-
Propranolol
- Class II
- Blocks Epi and Norepi
- Cause depression, nightmares, sexual dysfunction
- In diabetics may mask hypoglycemia
-
Amiodarone
- Class III
- Block cardiac K channel
- Very life saving
- Very fat soluble, has Iodine, 1/2 life 45 days
- No renal ex.
- Torsades de pointes
-
Dronedarone/Multaq
- Class III
- Amiodarone without the iodine
- MOA is unknown, properties of all
-
Bretylium Tosylate
- Class III
- Only used if Lido doesn't work
- Can aggrivate Dig tox
-
Sotalol
- Class III
- B blocker and K blocker
- Can cause exacerbation of heart failure
-
Tikosyn
- Class III
- Blocks K outflow
-
Ibutilide/Corvert
- Class III
- Promotes Na influx
-
Class VI
- Verapamil and Diltiazem
- Inhibits influx of Ca
-
Adenosine
- Acts at purine receptor
- T1/2 of 1-10 sec
- Contra in asthma, COPD, or Sick sinus syndrome
-
Regadenoson
- Related to adenosine
- Used in Radionuclide myocardial imaging
-
Diltiazem
- Benzothiazepine
- Use sustained release
- Incompatible with furosemide solution
- Watch for shortness of breath and edema
-
Verapamil
- Phenylalkylamine
- Treat chronic stable angina
-
Bepridil
- Phenylalkylamine
- Chronic stable angina
-
-
Nifedipine
- 1,4 Dihydro
- Chronic stable angina
-
Nicardipine
- 1,4 Dihydro
- Hypertension and CSA
-
-
Amlodipine
- 1,4 Dihydro
- Never abruptly stop
- Pass into mothers milk
-
Cleviprex
- 1,4 Dihydro 3rd generation
- Injectable emulsion when oral meds dont work
- Severe hypertension
- Contra in soy and egg allergy
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