-
Framingham Cohort
population: men and women who had not developed CVD symptoms or no history of MI, heart attack or stroke
Reason: ID common risk factors of CHD
Primary
-
MR. FIT
Population: makes with one or more risk factor
Reason: study effects of lowering elevated serum cholesterol, diastolic pressure, and stopping smoking and if it decreased CHD mortality
Primary
-
HPS
Population: men and women 40-80 that had TC >135 and an increased risk of CHD from previous Mi, disease of arteries, DM, or HTN
Reason: examine effect of lowering LDL on CVD risks, regardless of baseline LDL
Secondary
-
CARDS
Population: men and women with type II diabetes, no MI or CHD history and LDL < 160
Reason: test if there is a decrease in major CV occurrence and if diabetics should be placed on statins
Primary
-
ASCOT
Population: men and women with HTN and at least 2 risks
Reason: decrease risk of nonfatal MI or fatac CHD event
Primary
-
TNT
Population: men and women with CHD, LDL >130 TG <250
Reason: test the difference between patients on atorvastatin 10mg and 80mg per day
Secondary
-
SPARKLE
Population: ment and wonen at risk for stroke and no history of CHD LDL >100 and had previous stroke
Reason: see if statins can decrease the risk of stroke
- CHD primary
- Stroke secondary
-
PROVE-IT
Population: men and women with acute coronary artery disease in the past 10 days
Reason: test pravastatin or atorvastatin in patients with MI in addition to ASA, stroke or rehospitalization
Secondary
|
|
