-
fibrillary astrocytoma
- grey/white matter junction in cerebral hemisphere
- NO CAPSULE
- invasive growth of well-differentiated astrocytes
- mean survival 6-8 yrs
-
glioblastoma multiforme
- most common malignant adult CNS tumor
- invasive growth (butteryfly pattern) crosses the corpus callosum
- pseudopalisading (line of cells surrounding an area of necrosis), high mitotic activity
- mean survival 1 yr, very poor prognosis
-
pilocytic astrocytoma
- most common benign CNS tumor of children
- cerebellum
- well demarcated
- cystic lesion with a mural node (node growing on the wall of the cyst)
- pilocytic astrocytes, rosenthal fibers (thick eosinophilic processes of astrocytes)
- very good prognosis b/c well demarcated
-
oligodendroglioma
- malignant tumor of the oligodendrocytes
- older pts
- frontal lobe, may present with seizures
- fried egg appearence, calcifications(can be diagnosed by x ray), chicken wire capillary pattern (anastamosing capillary network)
-
ependymoma
- children - 4th ventricle
- adults - spinal cord
- well circumscribed, epithelial-like cells arranged in perivascular pseudorosettes (around a capillary) and true rosettes (around empty space)
- causes obstructive hydrocephalus
- mean survival 4 yrs
-
medulloblastoma
- malignant tumor derived from the granular cells of the cerebellum (neuroectoderm)
- ataxia + headaches and seizures
- cerebellar vermis
- small blue round cell tumor
- homer wright rosettes around a central fibrillary core
-
menigioma
- most common benign tumor in adults F>M
- benign tumor of the arachnoid cells
- never grows inside the brain
- nodule compresses the underlying brain tissue without invasion
- spindle shaped cells, whorls, psammoma bodies
-
primary CNS lymphoma
- young and middle aged adults
- deep white matter, relatively well circumscribed nodule with central necrosis
- angiocentric pattern - cells accumulate around blood vessels
- very poor prognosis
- associated with EBV infection
-
dermoid cyst
lined by squamous epithelium and filled with keratin, often in the temporal region
-
colloid cyst
- 3rd ventricle, solitary cysts lined by columnar epithelium, filled with mucoid material
- commonly produce hydrocephalus by blocking the foramen of monro
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