A. easily disseminated/transmitted from person-to-person
B. moderate morbitity rates
C. Rickettsia prowazekii
D. Francisella tularensis
E. require specific enhancements of CDC's diagnostic capacity and disease surveillance
F. high mortality rates
G. major public health impact
H. moderately easy to disseminate, low mortality rates
I. Bacillus anthracis
J. Coxiella burnetii
K. Brucella spp.
L. Yersinia pestis
1. Catergory A agents - A. easily disseminated/transmitted from person-to-person, D. Francisella tularensis, F. high mortality rates, G. major public health impact, H. moderately easy to disseminate, low mortality rates, I. Bacillus anthracis, L. Yersinia pestis
2. Catergory B agents - B. moderate morbitity rates, C. Rickettsia prowazekii, E. require specific enhancements of CDC's diagnostic capacity and disease surveillance, J. Coxiella burnetii, K. Brucella spp.
What virulence factor of Bacillus anthacis is the most important in causing infection?
A man develops a black eschar surrounded by a ring of vesiculation upon 5 days of visiting the Middle East. 8 days later he has returned home to the States and the eschar has now enlarged and covers the previously vesicular area and the surrounding edema has diminished. He comes into your office with concerns that he may have gangrene or "something". The ulcer is not painful, but it has a coal-black necrotic center. You collect fluid from the focal lesion, gram stain it and exam it under a microscope. The gram stain shows large, gram+ bacilli in chains. What is the most likely diagnosis and what pathogen is involved?
C. Anthrax; Bacillus anthracis
A patient comes into your office presenting with respiratory distress, a low grade fever, dry hacking cough and malaise. You perform an X-ray. The x-ray shows mediastinal hemorrhage and pleural effusion with massive pulmonary edema. You collect a sample of sputum, gram stain it and exam it under a microscope. The gram stain shows large, non-motile, gram+ bacilli in chains. What is the most likely diagnosis and what pathogen is involved?
B. Inhalation Anthrax; Bacillus anthracis
What is the most important virulence factor for Yersinia pestis in causing infection?
Type III secretion - Yersinia outer membrane protein, low calcium response
A 42-year old man comes into your office presenting with fever, lymph node swelling, vasculitis, petechial bruising and gangrenous necrosis on his extremities. He is currently living in a rat-infested environment. You take a sample of his blood, gram stain it and exam it under a microscope. You see gram- rods that have a "safety pin appearance". What is the most likely diagnosis and pathogen involved?
C. Bubonic plague; Yersinia pestis
What are the 4 different ways in which Francisella tularensis can infect humans?
biten by tick or deerfly
handling animal carcasses
eating/drinking contaminated food/water
inhalation of bacteria
Which pathogen causes Brucellosis in humans, can be contracted via drinking unpasteurized milk from infected cows and is a gram- coccobacilli?
Which pathogen causes Epidemic typhus in humans, can be contracted from human head lice, is fostered by poverty, overcrowding and poor sanitation, and is a gram- coccobacilli?
Which pathogen causes Q fever in humans and presents with a respiratory infection, along with atypical pneumonia, headache and fever, and is a gram- coccobacilli?