day 6

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As a result of an action potential, vesicles...

release their nuerotransmitters into the synapse

-voltage gated calcium channels open
Where are the voltage gated calcium channels concentrated?

near the synapse
Influx of Ca causes...

vesicles to move to the presynaptic membrane
Without action potential...

no neurotransmittter is released
Lowering the amount of the concentration of calcium around the axon terminal....

reduces the amount of neurotransmitter is released
Who discovered neurotransmitters?

Otto Loewi
What form do vesicles release Neurotransmitters?

exocytosis
what are receptors? (2)

proteins in the membrane of the post-synaptic cleft in which neurotransmitters molecules bind to proteins.

-will only bind to specific neurotransmitters
2 types of neurontransmitters

-small-molecule and peptide neurotransmitters
3 major types of receptors

-autoreceptor

-ionotropic

-metabotropic
quick description of Autoreceptors

-subset of receptors that are positioned on the pre-synaptic membrane

-when NT binds to autoreceptor it either inhibits or sitmulates the relase of NT
Ionotropic receptors
- -when NT(ligand) binds to I.R it causes immediate change in receptor
- * channel opens up usually allowing flow of ions to go in
-located on the post-synaptic
What happens when NT crosses the synapse?

-interacts with iontropic receptors to open channels on the postsynaptic membrane
Metabotropic receptors

-more prevalent than ionotropic

-when NT binds to them, causes a cascade of intracellular events to occur
what is a ligand?

molecule that ninds to another

ex) NT is a ligand to its receptor

Author

Anonymous

172264

Card Set

day 6

Description

chemical signaling

Updated

2012-09-20T23:43:31Z