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Gastrointestinal system
Anatomy
- Mouth
- Teeth
- Salivary glands
- Esophagus
- Stomach
- Small and large intestine
- Liver- bile
- Pancreas
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Purpose of the Gastrointestinal System
- Digestion and Absorbtion
- Detoxification
- Protective Barrier
- Hydration
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Gastorintestinal System
Pathologic symptoms
- Dysphagia- difficult swallowing
- vomiting
- Digested material
- Regurgitation
- Undigested material
- Diarrhea
- Icteric
- Jaundice
- Yellow discoloration
- Liver
- Weight loss
- PU/PD
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Gastrointestinal System
Terminology
- Dysphagia- difficulty swallowing, dental disease
- Dyschezia- Difficult or painful defication
- Melena- Bloody Feces, black in color, Indicates upper GI Bleed
- Hematamesis- Blood in Vomit
- Bile- Vomiting yellow bile reflux due to an empty stomach
- Anorexia- not eating and emaciation
- Pyrexia- fever
- Borgorygmus- bowel sounds, gas
- Tenesmus- Straining in pain for defication or urination
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Gastrointestinal System
Diagnostic Tests
- Blood Panel- Leukocytes, infections
- Pancreas- Elevated Amylase and Lipase
- Liver- Elevated Bilirubin, SGOT, SGPT, Alkaline Phosphate, GGT, bile acids
- Elevated PVC
- Maldigestion test
- Trypsin- Like Immunoreactivity (TLI)
- Folate and Cobalamine test
- Fecal- Parasites
- Malabsorption- sudden strain
- Fat Droplets
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SGOT
SGOT: Serum glutamic oxaloacetic transaminase, an enzyme that is normally present in liver and heart cells. SGOT is released into blood when the liver or heart is damaged.
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SGPT
SGPT: Serum glutamic pyruvic transaminase, an enzyme that is normally present in liver and heart cells. SGPT is released into blood when the liver or heart are damaged
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Gastrointestinal System
Diagnostic Tests
- Radiographs
- Stomach shape
- Obstruction (foreign body)
- Neoplasia
- Upper GI- Barium Study
- Used for foreign body or transit time
- Intussusception- intestine going into intestine
- Endoscopy
- Stomach, Duodenum and Colon
- Visualization for ulcers and neoplasia
- Tissue biopsy
- Noninvasive
- Biopsy and cultures
- Ultrasound
- Liver size and gall bladder
- Shunts
- Ultrasound guided biopsy
- Lymph nodes
- Intussusception
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Gastrointestinal System
Diseases- Stomach
Clinical Signs and History
- Vomiting
- Loss of appetite
- Salivating- Nausea
- Abdominal Pain
- Melena
- Polydyspsia
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Gastrointestinal System
Gastritis
Etiology
- Inflammation caused by continuous damage to gastric mucosa
- Infections
- Parvo Virus
- Distemper
- Viral
- Fungal
- Bacterial
- Toxins
- Ethylene glycol- antifreeze
- lead
- arsenic
- Plants and fertilizer
- Foreign objects
- Rocks
- Balls
- Plastic
- String
- Drugs
- NSAIDS
- Dietary indiscretion
- Hepatic
- Renal
- Neoplasia
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Gastrointestinal System
Gastritis
Diagnostic Tests
- Radiographs
- Blood panel
- Viral Screens
- Endoscopy
- Barium Study
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Gastrointestinal System
Gastritis
Treatment
- Dietary
- NPO for 8-12 hours
- Bland diet if no vomiting in a 12-24 hour period
- Antibiotics
- Antiemetics
- Reglan- metoclopramide
- Cimetidine (Tagamet)
- Ranitidine (Zantac)
- Protein Pump inhibitors
- Most potent agent to decrease stomach secretions and acidity
- Omeprazole (prilosec)
- 0.7 mg/kg PO SID
- Misoprostol
- NSAID ulceration prevention
- 2-5 mg/kg PO TID
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2 ligaments attached to the stomach
- hepatogastric
- hepatoduodenal
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nephropathy
A disease of the kidney. Also called renopathy
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hydronephrosis
swelling of the kidneys when urine flow is obstructed
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Gastric Dilation Volvulus
GDV or Bloat
Clinical Signs
- Distended abdomen
- Gas filled (ping)
- Dry heaves and salivation
- Grunting
- Collapse
- Hypotension and shock
- Arrhythmias
- Myocardial Ischemia
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Gastric Dilation Volvulus
GDV or Bloat
Etiology
- Dogs and Cattle
- Diet in Cattle
- No evidence in dogs
- Running or playing after eating (postprandial exercise)
- Cattle
- High protein diet
- gas production (alfalfa)
- Genetic Tendency
- Deep chested dogs
- Great danes, Rottweilers, Chows, Golden Retrievers, Akita, etc.
- Laxity of hepatogastric and hepatoduodenal ligament
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Gastric Dilation Volvulus
GDV or Bloat
Diognostic Test
- Radiographs
- Bloat
- Double bubble appearance
- Gas distention
- Spenomegaly
- EKG
- arrhythmias
- Blood Panel
- Acidosis
- anemia
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Gastric Dilation Volvulus
GDV or Bloat
Treatment
- Shock Treatment
- Fluids
- Corticosteroid
- Decompression
- Stomach tube
- Trocarization
- Surgery
- Gastrology
- Splenectomy
- Antibiotics
- Antiarrhythmics
- Lidocaine
- Procainamide
- Mexiletine (mexitil)
- Prokinetic Agents (Ileus)- enhances gastrointestinal movement
- Reglan
- Cisapride
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Gastrointestinal system
diseases of Liver
Clinical Signs and history
- Lethargic
- Vomiting and diarrhea
- Anorexia
- Fever
- Icterus
- Seizures
- Hepatic encephalopathy- brain disorder, seizures
- Elevated Ammonia
- Lactulose- sythetic, non digestible sugar
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Gastrointestinal system
diseases of Liver
Etiology
- Infections
- Bacterial
- Viral
- Fungal
- Autoimmune
- Neoplasia
- Idiopathic- unknown
- Chronic disease- failure
- Toxicity
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Gastrointestinal system
diseases of Liver
Diagnostic Tests
- Blood panel
- elevated liver enzymes
- Bile acids
- Radiographs
- Neoplasia
- Ultrasound
- Biopsy
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Gastrointestinal system
diseases of Liver
Treatment
- Antibiotics
- Amoxicillin
- Cephalosporines
- Metronidazole
- Nutritional support
- PEG tube or nasal gastric tube
- low protein diet and low fat (K/D)
- B Vitamins
- Corticosteroid
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Gastrointestinal system
diseases of Pancreas
Clinical Signs and history
- Vomiting and diarrhea
- Abdominal pain
- Fever and Anorexia
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Gastrointestinal system
diseases of Pancreas
Etiology
- Diet- pica (pattern of eating non-food materials)
- High fat diet
- Table scraps
- Liver Disease- pancreas
- Inflammation to pancreas
- Infections
- Trauma
- Schnauzers- high fat
- Due to idiopathic hyperlipidosis
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Gastrointestinal system
diseases of Pancreas
Diagnostic Tests
- Blood Panel
- elevated Amylase and Lipase
- Leukocytes
- Radiographs
- Hazy cranial abdomenal and peritonitis
- Ultrasound
- Thick pancreas
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Gastrointestinal system
diseases of Pancreas
Treatment
- Fluid Therapy
- Antibiotic therapy
- NPO for 72 hours
- Antiemetics
- Bland Diet
- Low Fat- I/D
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Gastrointestinal system
Hemorrhagic Gastroenteritis
HGE
- Caused by loss of fluids
- Bloody vomit and diarrhea
- Fever
- Lethargic
- Dehydration
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Gastrointestinal system
Hemorrhagic Gastroenteritis
HGE
Etiology
- Unknown
- Stress
- Diet Change
- Possible clostridium
- Breeds
- Primary in small dogs
- Toy Poodles, Dachsunds, Etc.
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Gastrointestinal system
Hemorrhagic Gastroenteritis
HGE
Diagnostic Tests
- Blood Panel
- Elevated PCV
- 50-80%
- Parvo Test
- Negative results
- Radiographs
- Normal
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Gastrointestinal system
Hemorrhagic Gastroenteritis
HGE
Treatment
- Fluid Therapy
- Treat dehydration and hemoconcentration
- Antibiotics
- Bland diet
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Gastrointestinal system
Inflammatory Bowel Disease (IBD)
Chromes
Introduction
- A group of gastrointestinal disease of stomach, small intestines and colon that are charactersitized by inflammatory cellular infiltrates in the lamina propria of these structures.
- Effects both dog and cats of any age or sex
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Gastrointestinal system
Inflammatory Bowel Disease (IBD)
Chromes
Etiology
- Abnormal mucosal immune response to certain causative factors and antigenic stimulation
- Food Allergy
- Dietary
- Stress and behavioral
- Heredity
- Idiopathic
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Gastrointestinal system
Inflammatory Bowel Disease (IBD)
Chromes
Clinical Symptoms
- Diarrhea
- Chronic or acute
- Continual or intermittent vomiting
- Vomiting
- Chronic or acute
- Continual or intermittent
- Anorexia and weight loss
- Tenesmus (or feeling that you constantly need to pass stools) hematechezia
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Gastrointestinal system
Inflammatory Bowel Disease (IBD)
Chromes
Diagnosis
- Blood profile
- High wbc count and low proteins as albumin
- Radiographs
- Fecal
- Endoscopey and tissue biopsy
- Definitive test
- GI Blood Panel- canine or feline specific lipase
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Gastrointestinal system
Inflammatory Bowel Disease (IBD)
Chromes
Treatment
- Chronic long term treatment can control disease process, but cannot cure
- Each case may require different combinations of medication and diet control
- Control diet- bland diet as I/D or D/d
- Prednisolone 1-2 mg/kg BID, then taper after one month
- Aziothioprine 2mg/kg PO SID x 7 days, then q EOD
- Sulfasalazine 25-50 mg/kg m2Cyclophosphamide 50 mg/kg m2
- Amoxicillin 10-25 mg/kg PO BID
- Reglan- antiemetic
- Carafate- gastric ulcer
- Famotadine- H2 blocker
- Metronidazole- anaerobic bacteria and antiinflammatory
- Budesonide- local acting corticosteroid to GI tract
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Urinary System
Anatomy
- Kidney
- Ureters
- Bladders
- Urethra
- Penis
- Vagina
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Urinary System
Purpose
- Filter and dispose Nitrogen waste
- Acid base regulation
- Chemical excretion
- Electrolyte, mineral, glucose and protein regulation
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Urinary System
Pathologic symptoms
- PU/PD
- Vomiting and diarrhea
- Uremic breath
- Anorexia
- Incontinence
- Weight loss
- Urias
- Oliguria
- Hematuria
- Anuria
- Pollakiuria
- Stranguria
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Urinary System
Terminology
- Anuria- Not urinating
- Stranguria- straining to urinate
- Oliguria- diminished urine production
- Pollakiuria- Frequent urination
- Hematuria- Bloody Urine
- Azotemia- High BUN and Creatanine
- Refers to renal disease
- Urolith (urolithiasis)
- Urinary calculi or stone
- Dysuria- Painful Urination
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Urinary System
Diagnostic Tests
- Blood Panel
- Azotemia
- Hyperphosphatemia
- Urinalysis- UTI (Cystitis) Inflammation
- Radiographs- Contrast cystogram
- Stones
- Contrast cystogram
- IVP
- Ultrasound
- Prostate
- Tumors
- Exploratory Surgery
- Biopsy
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Urinary System
Cystitis (UTI)
Clinical Signs and History
- Pollakiuria
- Stranguria
- Hematuria
- Dysuria
- Febrile- feverish
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Urinary System
Cystitis (UTI)
Etiology
- Infections
- Bacterial
- Viral
- Secondary pyelonephritis- kidney infection
- Bladder stones
- Urachal diverticulum
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Urinary System
Cystitis (UTI)
Diagnostic Tests
- Urinalysis
- Bacteria
- Proteinuria
- Urine culture and sensitivity
- Radiographs and cystogram
- Stone
- Neoplasia
- Blood Panel
- Kidney Disease
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Urinary System
Cystitis (UTI)
treatment
- Antibodies
- 7-14 days
- May be needed 6-8 weeks
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Urinary System
Urolithiasis (bladder Stone)
Cystic Calculi (urolith)
Clinical signs and History
- Dysuria and Hematuria
- Stranguria
- Vomiting and Diarrhea
- Lethargic
- Not Eating
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Urinary System
Urolithiasis (bladder Stone)
Cystic Calculi (urolith)
Etiology
- Dietary
- Infections
- Congenital (Anatomical)
- Urachal diverticulum
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Urinary System
Urolithiasis (bladder Stone)
Cystic Calculi (urolith)
Diagnostic Tests
- Urinalysis
- Cyrstals
- Radiographs
- Ultrasound
- Contrast cystogram and IVP
- Blood profiles
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Urinary System
Urolithiasis (bladder Stone)
Cystic Calculi (urolith)
Common Urolith
- Struvite
- Magnesium Ammonium phosphate
- Primate cats with FLUTD
- Dissolve crystals in acid PH of Urine
- C/D diet
- Calcium Oxylate
- Most common urolith seen in dogs
- S/D diet
- Urate
- 1.Dalmations- usually males with urethral obstruction
- Due to incomplete oxidation of uric acid which forms urate crystals Alkaline ph change to urine
- 2. Allopurinol- binds xanthine oxides to prevent uric acid production
- 15 mg/kg PO BID
- 3. U/D diet- Alkaline diet
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Urinary System
Urolithiasis (bladder Stone)
Cystic Calculi (urolith)
Treatment
- Antibiotics
- Dietary managment
- C/D
- Struvite (Alkaline
- S/D
- Calcium oxylate (Acidic)
- U/D
- Urate (Acidic)
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Urinary System
Urolithiasis (bladder Stone)
Cystic Calculi (urolith)
Surgery
- Cystotomy- surgical incision of the urinary bladder
- Nephrotomy- surgical procedure in which the kidney is cut
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Feline Lower Urinary Tract Disease
FLUTD
Feline Urological Syndrome
Clinical Signs and History
- Dysuria
- Hamaturia
- Pollakiuria
- Urinating
- Abnormal areas
- Frequent trips to the litter box
- Excessive licking of genitalia
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Feline Lower Urinary Tract Disease
FLUTD
Feline Urological Syndrome
Etiology
- Diet
- High in Magnesium and Ash
- Infections
- Alkaline PH urine
- Anatomical
- males
- Due to penis anatomy
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Feline Lower Urinary Tract Disease
FLUTD
Feline Urological Syndrome
Diagnostic Tests
- Physical exam
- Large painful and unexpressable bladder
- Distended penis
- Mucus plug
- Blue discoloration
- Urinalysis
- Struvite crystals
- Triple phosphate
- Blood Panel
- Azotemia
- Hyperkalemia
- Radiographs and Ultrasound
- Double contrast cystogram
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Feline Lower Urinary Tract Disease
FLUTD
Feline Urological Syndrome
Treatment
- Nonobstruction
- Antibiotics
- Diet management
- C/D diet Acid PH urine dissolves crystals
- Propantheline
- Anticholinergic
- Reduces bladder spasms and urge and incontinance
- 7.5 mg/kg PO every 3rd day
- Phenoxybenzamine
- Minimize reflex dysnergia
- Urethral outflow problems
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Feline Lower Urinary Tract Disease
FLUTD
Feline Urological SyndromeTreatment
Treatment
- Obstruction
- Urinary catheter
- Retro pulse 0.9% NaCL
- Leave urinary catheter in for 2-4 days
- Until hematuria has resolved
- Remove urinary catheter
- Cat urinating well by itself
- send home 24 hours later on antobiotics and C/D diet
- IV fluids
- Antibiotics
- E-collar
- Reccurring FLUTD
- Surgery
- Perineal urethromstomy (PU)
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Kidney Failure
Clinical Signs and History
- P/U P/D
- Lethargic
- Inactivity
- Weakness
- Anorexia
- Weight loss
- Vomiting
- Oral Ulcerations
- Stomatitis
- Uremia
- Retention of toxic waste materials
- Seizures and hypothermia
- Diarrhea
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Kidney Failure
Etiology
- Degenerative disease (aging)
- infections
- Neoplasia
- Congenital
- Basenji nephropathy
- Hydronephropathy
- Polycystic kidney
- Immune mediated
- Amyloidosis
- Abyssinians and Shar Pei
- Toxicity
- Ethylene glycol
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Kidney Failure
Diagnostic Tests
- Blood Panel
- Elevated BUN, Creatinine and phosphorus and anemia
- Urinalysis
- Specific gravity is <1.020
- Isosthenuria or Hyposthenuria
- Radiographs
- Evaluation of kidney size and shape
- Nephrocalcinosis
- Uroliths
- Ultrasound
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Kidney Failure
Treatment
- Fluid Therapy
- Iv Fluids
- Isotonic
- SQ fluids
- Cats
- Anemia
- Erythropoietin
- Vomiting
- H2 receptor antagonists
- Cimetidine (Tagamet)
- Ranitidine
- Reglan
- Antibiotics
- No Aminoglycosides
- Hyperphosphatemia
- Amphogel (aluminum Hydroxide)
- Dietary Management
- Low Protein
- K/D
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