Lecture 2 - MHC + TCR.txt

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The 4 classes of immunoglobulin super family
- MHC1
- MHC2
- TCR
- AB
MHC1 structure
- like a pita pocket
- 1 alpha chain – 3 domains
- 1+2 = binding pocket
- Beta 2 microglobulin – co protein not anchord
- CD8 t cells
- 8-10 AA in length
MHC2 structure
- two chains
- beta and alpha 2 in the mem
- CD4
- non-covalent association
- 13-20 aa in length
MHC1 is found on

all nucleated cells
MHC2 is found on
- APC
- Microglia
- thymic stromal cells
APC are
- macrophages/monocytes
- B cells
- Dendritic cells
HLA complex
- MHC gene
- Polygenic
MHC1 Loci
- A – alpha
- B – alpha
- C – alpha
- you can have up to 6 different MHC1
MHC2 Loci
- DP – beta alpha
- DQ – beta alpha
- DR – beta alpha
- you can have up to 12 different MHC2s
involved in Cytosolic pathway
- endogenous
- host protein
- intracellular pathogen – viral dna
- MHC1
- CD8
- Cytotoxic
involved in Endocytic pathway
- Microbe
- toxin
- extracellular self protein
- MHC2
- CD4
- inflamation
cytosolic pathway steps
- cytosolic protein gets ubiquinated
- goes to the proteasome gets degraded into correct size
- TAPs move it into the ER
- Calnexin and Calreticulin associate the protein with MHC1
- moves to the surface
Endocytic Pathway
- extracellular proteins are phago
- degraded in phagolyso
- invariant chain (Ii) keeps MHC2 clear
- binds with phagolyso
- invariant degrades
- calnexin helps protein into place
- presented on cell surface
cytokines
- small soluable proteins that deliver signals
- paracrine – short distance
- autocrine – self signaling
TCR co protein

CD3 complex → three double proteins
Thymocyte

developing t cell with no TCR
Gene rearrangement is the first step in t cell development
steps in TCR formation
- alpha surrogate (pre-TCR)
- double positive
- TCR and CD3
- Positive selection

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jselim

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Lecture 2 - MHC + TCR.txt

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Updated

2012-09-16T13:26:36Z

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