Lecture 1 - innate.txt

Normal flora – microbes that co-exist with humans without causing disease

microbes capable of causing human disease

the establishment of proliferating microbes on the skin or mucous membranes

organisms that do not cause disease in healthy individuals but in immune-suppressed

the proliferation of microbes in tissues with the concomitant induction of the immune system.

the proliferation of microbes in tissues, immune response and resulting damage and/or impairment of bodily functions.

organisms are on the mucous membrane

organism has moved into the body they has penetrated the skin

A pathogenic organism but is in a state where you are carrying and replicating but do not present with disease

a state where there is damage to cells or tissues

• Phagocytosis
• Complement (Alternate Pathway)
• Inflammation
• Cytokine Release
• NK cell killing
• (0-96 hours)

• Long lived
• Innate – Tissue
• Phagocytosis
• Cytokine secretion
• antigen presentation (Adaptive)

• short lived
• Innate – blood
• Phagocytosis
• Granular release of antibacterial compounds

• Rubor – Redness
• calor – Heat
• dolor – Pain
• tumor – Swelling

Mast cells

body's attempt to confine non destroyed antigen, Chronic inflammation

Fever

Fever

Fever

• Interfere with viral replication
• activation of NK cells

• interfere with viral replication
• activation of NK cells

genetic defect causing deficiency

immune suppressive agents (HIV)

Decreased numbers

• X linked or Autosomal recessive
• NADPH affected
• formation of granulomas
• More susceptible to catalase oxide positive bacteria
• treated with gama interferon and prophylactic antibiotics

• CD18 defect -migration molecule
• Autosomal recessive
• impaired T,B cell function
• infections with encapsulated bacteria

• Defect in lysosome fusion
• reduced killing ability
• can present as albino

• Specificity
• Activation
• Memory
• self-nonself