SA Med, E1, Canine Viruses

hepatocytes, epithelial cells (like those in kidney and eye)

infectious hepatitis

adenovirus type 2 because it also provides cross protection for type 1 and type 1 vx causes virus shedding in urine and blue eye

• shed in all secretions during acute infection; shed in urine after 6-9 months
• oronasal exposure --> disseminates to all tissues

GI, Resp, Neuro

• adeno-resistant
• distemper- easily destroyed
• both very contagious, esp. if unvaccinated

variable but respiratory often first and coicide with 2nd part of diphasic fever

• foot pads and nose
• hypoplasia of enamel

chewing gum seizures and myoclonus

2-6 months w/inadequate vaccination and hi risk place like shelter

inclusion bodies seen in circulating lymphocytes, monocytes, neutrophils, and RBCs

rising serum neutralizing Ab or specific IgM titer is suggestive of recent infection (IgG is of NO benefit--will show up w/vacc.)

supportive only, disease is progressive and mortality is hi in puppies (consider euthanasia)

• bordetella bronchiseptica
• canine parainfluenza virus
• canine adenovirus type 2

• intranasal/injectable vx are available (may just reduce symptoms)
• usu.self limiting cough but very contagious/acute onset