-
Imaging of pyelonephrtitis
- Indicated once fever persists for 5-7d of tx.
- U/S or CT
- Drain abscess and culture
-
Endocarditis tx
- Empiric: vanc + gent
- Virdans: 4 weeks ceftriaxone
- Staph: Oxacillin, nafcillin, cefazolin. If prosthetic, add rifampin
- Fungal: Amphotericin and valve replacement
- Staph epidermidis or MRSA: Vanc + gent
- Enterococci: Amp+ gent
- HACEK: ceftriaxone
- Resistance: Add aminoglycoside
- Surgery if CHF, rupture, prosthetic, block, fungal, abscess, AV block, emboli which on abx
-
HACEK
- Haemophilus aphrophilus and parainfluenza
- Actinobacilus
- Cardiobacterium
- Eikenella
- Kingella
-
Endocarditis ppx
- Amox
- If pen all, clinda, azithro, or clarithro
-
Lyme rash timing and prevalence
5-30days after tick bite. 85-90% of pts
-
Lyme joint involvement
- 60% of pts
- Oligo
- 24000 WBC in aspirate (nondistinguishing)
- Knee most common
-
Neuro Lyme
- 10-15%
- Bell palsy
- Meningitis, encephalitis, CN palsy
-
Cardiac lyme
- 5-10%
- AV block, Myocarditis, ventricular arrythmia
-
Lyme tx
- Rash: doxy or amox
- Joint or bell: doxy or amox
- Cardiac or neuro: IV ceftriaxone
- Tick bite IDed as ixodes scapularis, attached longer than 24hrs, engorged, or endemic area: 1 dose of doxy
-
Risk of transmission of HIV order
perinatal, anal, needle stick, oral receptive, vaginal receptive, vaginal insertive
-
CD4 >200 infections
Shingles, HSV, TB, candidasis, bacterial pna
-
HIV test
- ELISA
- confirmed by Western
- infants - PCR or viral cx
-
Tx of HIV
- CD4 < 500, viral >100,000, or opportunistic infection
- -emtricitabine (NRTI), tenofovir (NRTI), and efavirenz (nonNRTI)
- -if resistant, 3 drugs with at least 2 classes of NRTIs, nonNRTIs, protease inh
- -Then entry inhibitors (enfuvirtide or maraviroc) or integrase inh (raltegravir)
-
Sides of HIV meds:
- Zidovudine
- Stavudine and didanosine
- Abacavir
- protease inh
- indinavir
- tenofovir
- efavirenz
- Anemia
- periph neuropathy, pancreatitis
- hypersens, SJS
- Hyperlipid, hyperglycemia
- nephrolithiasis
- renal insufficiency
- teratogenic - use a protease inh instead
-
Pregnant HIV tx
- Efavirenz is teratogenic
- Keep on other meds or start meds if indicated
- If mom is fine, tx during 2nd and 3rd trimesters
- Intrapartum +6 weeks zidovudine for baby
- If CD4 <350 or viral >1000 - Csection
-
Beta lactams
- Penicillins,
- cephalosporins,
- carbapenema,
- aztreonam.
-
Bugs tx by pen
- Strep viridans,
- strep pyogenes,
- oral anaerobes,
- syphilis,
- leptospira
-
Bugs tx by amp and amox
- All of pen plus
- ecoli,
- lyme,
- gram neg (HELPS) Hflu, Ecoli, Listeria, Proteus, Salmonella
-
Amp/amox is best initial tx for
- Otitis media
- dental
- endocarditis ppx,
- limited lyme,
- pregnant uti,
- listeria,
- enterococcal.
-
Oxacillin, dicloxacillin, nafcillin are used for
- Skin (cellulitis, impetigo, erysipelas),
- staph (endocarditis, meningitis, bacteremia),
- sensitive osteo or septic joint.
-
Piperacillin, ticarcillin, azlocillin, mezlocillin bug and are best initial for
- Gram neg (Ecoli, proteus) and pseudomonas.
- Cholecystitis, asc cholangitis,
- pyelo,
- bacteremia,
- hospital acquired pna,
- neutropenia fever.
-
Bugs resistant to all cephalosporins
- Listeria,
- mrsa,
- enterococcus
-
Bugs tx by all cephalosporins
- Strep a, b, c, viridans,
- Ecoli,
- klebsiella,
- proteus
-
Pen allergy alternative
- If rash, use cephalosporin.
- If anaphylaxis, use non beta lactam abx
-
First gen cephalosporin
- Cefazolin,
- cephalexin,
- cephradrine,
- cefadroxyl.
- Staph, strep, Ecoli.
-
2nd gen ceph
- Cefotetan,
- cefoxitin,
- cefaclor,
- cefprozil,
- cefuroxime,
- loracarbef.
- 1st+ better for anaerobes and gram neg. Most good for upper resp
-
Cefotetan or cefoxitin
- 2nd gen ceph.
- Best initial for pid with doxy.
- Inc bleeding risk and disulfiram like
-
3rd gen ceph
- Cedtriaxone,
- cefotaxime,
- ceftazidime
-
Ceftriaxone
- 3rd gen.
- First line for pneumococcus.
- Meningitis,
- comm pna with a macrolide,
- gonorrhea,
- lyme in heart or brain.
- Neonates can't metabolize it in biliary.
-
Cefotaxime
- 3rd gen ceph.
- Better in neonate.
- Good for SBP
-
Ceftazidime
- 3rd gen cephalasporin.
- Pseudomonal
-
Cefepime
- 4th gen cephalasporin.
- Better at staph.
- Used for neutropenia fever, vent pna
-
Carbapenems
- Imipenem, meropenem, ertapenem, doripenem.
- Resistant gram neg. Neutropenia fever.
- All but ertapenem cover pseudomonas.
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