Med Chem GI

Bile acid sequestrant, an adjunct to diet and exercise

• Amoxicillin
• Clarithromycin
• Tinidazole
• Rifabutin

H2 blocker, CYP 450 inhibitor, Short half-life, acidifies urine.

• H2 blocker, NO CYP 450 inhibition
• Must stagger dose with antacids to increase bioavail.

H2 blocker, no CYP inhibition

• H2 blocker, 90% Bio, no CYP inhibition
• May cause increase transaminase levels (liver enzyme)

• PPI,CYP inhibitor, racemic (R is metabolized by 2C19, S by 3A4) 
• Can decrease Ca+ dissolution and bone resorption

PPI, S enantiomer of omeprazole

PPI, CYP metabolized use caution in severe impairment

PPI, Taken with or without food, can accumulate with hepatic dysfunction.

PPI, is not a CYP inhibitor

PPI, pure enatiomer of Prevacid

Makes mucus more protective, 90% is exreted in feces, little to no systemic effect. can decrease absorption of other drugs.

Used to prevent ASA and NSAID ulcers, Increases Bicarb and mucus production, Contraindicated in pregnant women.

Antacid

Antacid

Antacid

antacid

antacid

antacid

antacid

• In renal failure dont use Alumin or Mag
• Can get rebound hyperacidity after cronic use.

• Anticholinergic and antispasmodic (Belladonna)
• Decreases GI secretions, spasticity
• Take 30 min before meal

• Anticholinergic and antispasmodic (Belladonna)
• Decrease GI secretions
• Dosing for children is weight based

• Antichol and antispas (Belladonna)
• helps with N/V
• adjunct in IBS therapy

• Quatrenary anticholinergic
• Treat peptic ulcer
• + charge so less cross of BBB

Quatr antichol

Quatr antichol

Quatr antichol

• Treat functional/irritable bowel syndrome
• Antispasmodic

• Metamucil
• Citrucel
• Mitrolan

• Mineral Oil/Milkinol
• increase the excretion of fat-soluble vit.

• Docusate
• Ex-Lax
• Colace

• Glycerin suppositories/Colace
• Lactulose/Cholace

• Misc Lax
• increases Co2 = increases Pressure

• Treat IBS
• Increases Cl- WITHOUT altering K or Na, increases GI motility (acts like a saline lax)
• Very little systemic effect

Treat IBS, but withdrawn from the market

• Glucocorticoid for treating Crohn's
• Relieves inflammation

• TNF inhibitor
• Treat croh'n and Rheumatoind Arth.
• can give relief up to 12 weeks

• Treat Crohn's and MS
• Ultimately inhibits the inflammatory cascade

• Azathioprine/Imuran
• Mercaptopurine
• Methotrexate
• Cyclosporine

• Aminosalicylate
• Treat ulcerative colitis

• Aminosalicylate
• Treat ulcerative colitis
• tones down immune response

• Aminosalicylate
• Keeps ulcerative colitis in remmision
• Is cleaved in the gut by bacteria, helps with local effect.

• Aminosalicylate
• Treat UC and RA
• HAs an anti-infective property

• Anti-diarrheal antibiotic
• Treat Travelers diarrhea caused by noninvasive E.Coli

• Anti-diarrheal
• Slows GI motility
• Has Atropine in it to keep people from abusing

• Anti-diarrheal
• Inhibits smooth muscle contraction and slows GI motility

• Anti-diarrheal, NV, constipation
• Coats the linning of the gut
• Stool will gray-black

Posterior Pituitary Hormone product that helps diarrhea

• Treat short bowel syndrome
• Helps people absorb water
• Watch for Pediatric gasping syndrome

• Antiflatulent
• A surfactant
• Miracle drug for crying babies

• antiflatulent
• High surface area to absorb
• Can absorb wanted drugs

• Lipase Inhibitor
• Manage obesity
• Keeps you from breaking down and using fat.
• Prevents absorption of fat soluble vit.

• Treat diabetic delayed GI emptying and GERD
• Sensitizes GI to acetylcholine increaseing peristalsis
• ***Drug induced parkinsons****

• Nocturnal heartburn
• Can cause QT elongation (been withdrawn)

• GI stimulant increase acetylcholine, increase peristalsis
• Prophylacticly after abdominal surgery

• GI stimulant
• Peripheral only Mu-receptor opioid antagonist
• Doesnt take away the pain relief aspect of opioid

• GI stimulant
• Used for pt on continuous oipiod use
• + charge doesnt cross BBB

Gastric acidifier

Relives constipation and asan adjunct in biliary stasis

Dissolves Gall stones over a period of months

Oral yeast infection

canker/cold sores

oral yeast

Gingivitis

Oral inflammation

Treat lack of saliva

treat dry mouth caused by Sjogren syndrome

Aphthous ulcers

Removal of dietary phosphate

Advantage over carbonate resin is that it will maintain bicarb levels.

Relax anal sphincter to treat anal fissure