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Fibric Acid Deriatives include:
- fenofibrate (Tricor)
- gemfibrozil (Lopid)
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These decrease the hepatic synthesis and secreation of VLDL; reduce triglycerides
- Fibric Acid Deriatives such as
- fenofibrate (Tricor)
- gemfibrozil (Lopid)
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________ inhibits synthesis and secretion of VLDL and LDL, increases HDL, and can be used in combination with other lipid loweing agents.
- Vitiamin B3 Niacin
- ex. Nicobid
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Some side effects of Niacin (Nicobid) are:
Hypotension, GI irritation, Pruritis (itching)
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Bile-Acid Sequesternants:
Bind with bile acids in the intestine forming insoluble complex and excreted in feces.
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BileAcid Sequesterants include:
- –Cholestyramine – (Questran)
- –Colestipol - (Colestid)
- –Colesevelam - (Welchol)
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BileAcid Sequestrants:Therapeutic Uses
•Treatment of hyperlipidemia–Decrease the triglyceride levels –Increase HDL by as much as 25%
•Available as a dry powder–Must be mixed with liquid or soft food–Ability to bind many drugs
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 High density lipo-proteins:
- Carry fats away from arteries
- Generally higher in women until menopause
- Increase with physical activity
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Low density lipo-proteins:
- Affinity for coronary arteries
- Have more cholesterol
- Low LDL are desirable
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Non-modifiable risk factors for CAD:
- Age–Middle-age
- Gender–Male >women until age 60
- Race–Whites > blacks
- Genetic predisposition (Family history)
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Modifiable Risk factors:
- •High serum lipids
- •HTN
- •Smoking
- •Diabetes Mellitus
- •Obesity
- •Sedentary lifestyle
- •Stress
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Serum Lipids Lab values for:
-Serum cholesterol
-Fasting triglycerides
Serum cholesterol > 200mg/dl–Liver produces cholesterol
Fasting triglycerides > 150 mg/dl
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HMG-CoA Reductase Inhibitors (Statins) work by?
- -Inhibiting HMG-CoA reductase (Enzyme used by the liver to produce cholesterol)
- -Lowers the rate of cholesterol production
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Statins Include:
- •Atorvastatin- (Lipitor
- •Fluvastatin - ( Lescol)
- •Lovastatin - (Altocor / Mevacor)
- •Pravastatin - (Pravochol)
- •Rosuvastatin - ( Crestor)
- •Simvastatin - ( Zocor)
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Do not take with grapejuice with:
Statins, because it may cause toxicity
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Rhabdomyolosis a side effect of Statin drugs is:
- the break down of skeletal muscle, the byproducts of skeletal muscle destruction accumulate in renal tubules.
- •Causes acute renal failure
- •Crush injuries, toxic effect of drugs, extremes of exertion, sepsis, shock, severe hyponatremia
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