1. Dx: Major Depressive Disorder
    4/8 for 2 weeks with depressed mood or anhedonia: Sleep, interest, guilt, energy, concentration, appetite, psychomotor, suicide
  2. Atypical Major Depressive Disorder
    Increased sleep and appetite
  3. Dx: Neurotic Depression
    Chronic mild to moderate anxiety and depression
  4. Dx: GAD
    • Excessive anxiety/worry for at least 6 months 3/6: restless, easily fatigued, difficulty concentrating, irritable, muscle tension, insomnia
    • Dx: PTSD
    • Re-experience in at least 1 way (Intrusive recollection, flashbacks, nightmares, physiological distress or physical response to cues resembling event) Avoidance in at least 3 ways (avoiding thoughts, feelings, conversations, activities, people, places associated with events, inability to recall part of trauma, decreased interest in activities, estrangement, restricted affect, sense of shortened life)
    • Increased arousal in at least 2 ways (sleep disturbance, irritability/angry outbursts, hypervigilance, exaggerated startling, decreased concentration)
  5. Complex PTSD
    PTSD criteria and affective disregulation, poor impulse control, dissociation, somatization, self-destructive activities, preoccupation with perpetrator
  6. Dx: OCD
    Obsessions: Intrusive/Inappropriate/Interfering, not real-life problems, attempts made to ignore or neutralize, recognized as product of self Compulsions: Repetitive behaviors or mental acts in response to obsessions aimed at preventing or reducing distress, not realistically connected
  7. Dx: Bipolar Type I
    3/7 with euphoria or 4/7 with irritability for at least 1 week: Distractability, Insomnia, Grandiose, Flight of Ideas, Activities, Speech, Thoughtlessness -Mania because of disfunction
  8. Dx: Bipolar Type II
    • 3/7 with euphoria or 4/7 with irritability for at least 1 week:
    • Distractability, Insomnia, Grandiose, Flight of Ideas, Activities, Speech, Thoughtlessness -Hypomania because no disfunction, also need depressive episode (4/8 SIGECAPS)
  9. Dx: Schizophrenia
    2 or more for 1 month psychosis symptoms: Delusions (if bizarre no other symptoms needed), hallucinations, disordered speech, disturbance of behavior, negative symptoms -Disfunction-Over at least a 6 month period -Not schizoaffective, mood, substance, medical
  10. Dx: Schizophreniform
    Psychosis/schizophrenia symptoms for 1-6 months
  11. Dx: Schizoaffective
    Psychosis and mania/depression/mixed where psychosis persists with stable mood for 2 weeks; mood disorder prominent longitudinally
  12. Dx: Delusional disorder
    Non-bizarre delusions for 1 month with otherwise intact functioning
  13. Dx: Brief psychotic disorder
    Psychotic for less than 1 month - self-resolves
  14. Dx: Shared psychosis
    • Shared delusion with close contact
    • Dx: Conversion disorder
    • Caused by hypofunction in dominant hemisphere 1 or more symptoms indicating neurological disorder, with related psychological factors, not feigned or fully explained by medicine that causes distress or impairment (not pain or sexual dysfunction)
  15. Dx: Somatization disorder
    Starting before 30 and lasting several years -4 pain symptoms, 2 GI, 1 sexual and 1 pseudoneurological
  16. Dx: Hypochondriasis
    Preoccupation with fears of having (or thinking one has) a serious disease based on misinterpretation of physical signs, causing stress/impairment and lasting at least 6 months, with inability to be reassured
  17. Dx: Pain disorder
    Pain causing distress or impairment that cannot fully be explained that has psychological factors
  18. Dx: Body dysmorphic disorder
    Preoccupation with imagined (or exaggerated) defect leading to distress or impairment
  19. MOA: MAOI
    Block MAO from breaking down catacholamines, A - NE, Epi, 5HTB � Dopamine
  20. Tranylcypromine
  21. Phenelzine
  22. SE: MAOI
    Hypertensive crisis (with sympathomimetics or tyramine)
  23. CI: MAOI
    CHF, liver disease, pheochromocytoma
  24. MOA: TCA
    Inhibition of re-uptake of NE (5HT)
  25. Amitripytyline
  26. Imipramine
  27. SE: TCA
    Anticholinergic (dry mouth), weight gain, sedation, orthostasis, prolonged QRS Serotonergic (sexual dysfunction)
  28. Overdose: TCA
    Alkalinize serum
  29. MOA: SSRI
    Inhibition of re-uptake of 5HT
  30. Fluoxetine
  31. Paroxetine
    SSRI (Class D)
  32. Sertaline
  33. Citalopram
  34. SE: SSRI
    Nausea, sexual dysfunction, sleep, extrapyramidal, hyponatremia, QT prolongation, Anti-platelet, CYP2D6 Inhibition
  35. CI: SSRI
    Tamoxifen (CYP2D6 Inhibition)
  36. MOA: SNRI
    Inhibit re-uptake of 5HT and NE (some dopamine)
  37. Venlafaxine
  38. SE: SNRI
    Nausea, sexual dysfunction, sleep, extrapyramidal, hyponatremia, QT prolongation, antiplatelet effects, increase in BP and HR
  39. MOA: Buproprion
    Inhibit re-uptake of dopamine (NE)
  40. SE: Buproprion
    Nausea, tremor, agitation, insomnia, psychosis, seizures
  41. Zyban
    Buproprion derivative for smoking cessation
  42. MOA: Mirtazapine
    Tetracyclic; Inhibition of alpha-2 (increased 5HT, NE)
  43. SE: Mirtazapine
    Sedation, dizziness, weight gain, orthostasis, constipation, dry mouth, agranulocytosis
  44. MOA: Trazadone
  45. SE: Trazadone
    • Sedation
    • Beta blockers
    • B1 - HR, lipolysis, renin
    • B2 - Smooth muscle relaxation, tremor reduction
    • Don't impair cognitive function
  46. MOA: Propranolol
    Non-selective beta blocker
  47. CI: Propanolol
  48. MOA: Atenolol, metopropol
    B1 Inhibition
  49. MOA: Benzodiazepines
    Open more GABA channels A1 � sedation A2/3 � Anxiolysis A4 - Muscle relaxation
  50. SE: Benzodiazepines
    Dependence, tolerance, withdrawal, abuse
  51. Chlordiazepoxide
    Benzodiazepine (short)
  52. Diazepam
    Benzodiazepine (short)
  53. Alprazolam
    Benzodiazepine (long)
  54. Lorazepam
    Benzodiazepine (long)
  55. MOA: Benzodiazepine-like drugs
    GABA A1 - Sedation (short acting)
  56. Zolpidem
    Benzodiazepine-like drug (sedation)
  57. MOA: Barbituates
    Increase lenght of GABA channel opening
  58. Phenobarbital
  59. SE: Barbituates
    Tolerance, linear kinetics (overdose), drug interactions
  60. Flumazenil
    Emergency treatment for benzodiazepine overdose
  61. MOA: Flumazenil
    Neutral ligand for GABA receptors (competitive inhibition)
  62. MOA: Buspirone
    5HT receptor partial agonist (anxiolytic)
  63. Trazodone
    Helps people fall asleep and stay asleep, less potential for abuse
  64. MOA: Lithium
    Alters sodium transport, decreases inositol recirculation
  65. SE: Lithium
    Narrow therapeutic window Initial - nausea, fatigue Persistant - tremor, edema, weight gain, polydipsia/polyurea (antagonism of ADH receptors), nephrotoxicity, thyroid, confusion, ataxia, leukocytosis, skin, arrhythmias
  66. Drug interactions: Li
    Drugs that Increase Li: ACE inhibitors, Thiazide diuretics, NSAIDS Drugs that decrease Li - K-sparing diuretics
  67. MOA: Valproate
    Increases GABA
  68. SE: Valproate
    Narrow therapeutic window Sedation, tremor, weight gain, nausea, diarrhea, alopecia, neural tube defects, increased LFTs, platelet disfunction, pancreatitis, agranulocytosis
  69. MOA: Carbamazepine
    Na channel modulation
  70. SE: Carbamazepine
    Narrow therapeutic window Enzyme induction and toxicity, GI, CNS, leukopenia, thrombocytopenia, edema, rashes, hyponatremia (increased ADH)
  71. MOA: Lamotrignine
    Decreased glutamate and aspartate
  72. SE: Lamotrignine
    CNS, severe rashes
  73. MOA: Typical Antipsychotics
    D2 blockade (positive psychotic symptoms)
  74. Chlorpromazine
    Typical Antipsychotic
  75. Haloperidol
    Typical antipsychotic
  76. SE: Typical antipsychotics
    Extrapyramidal symptoms, prolactin, sexual dysfunction, orthostasis, QT prolongation, Acute dystonic rxn, tardive kinesis, neuroleptic malignant syndrome
  77. MOA: Atypical antipsychotics
    5HT (D2) blockade
  78. Clozapine
    Atypical antipsychotic
  79. SE: Atypical antipsychotics
    Hypotension, weight gain, dizziness, increased LFTs, increased glucose, increased lipids
  80. SE: Clozapine
Card Set
Psych Medication