Oncogene lecture

Oncogene?

Normal gene that causes cancer when mutated.
Oncogenic-retrovirus mechanism?

Virus acquires normal host gene (proto-oncogene), mutates it (oncogene), and incorporates it back into genome
3 mechanisms of expressing oncogenes in humans since virus-induced cancers are the exception?
- 1. structural mutation: EGF R is always "on" b/c of mutation
- 2. regulatory mutation: promotor is mutated to always "on"
- 3. translation of gene: put in wrong place and overlyexpressed
Tumor arise from a single or multiple mutations?

Tumors arise from MULTIPLE mutations!
Familial cancer syndrom (inherited cancer genes) are common or rare?
2 Acquired mutations of a single cell are common or rare?

familiar cancer sydrome (aka inherited cancer genes) are RARE

2 acquired mutations is COMMON
Two-hit hypothesis

It takes two mutated genes to cause cancer.
Tumor supressor gene vs. oncogene?

Tumor supressor gene = p53, tries to repress expression

Oncogene = overly expressed growth factor or receptor (EGF R)

Author

sbandzar

167779

Card Set

Oncogene lecture

Description

med school

Updated

2012-08-28T05:44:26Z

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