What is current dogma regeneration of nervous system?
Can't happen, but did happen in a limited fashion in one patient
What part of the brain did limited neurogenesis occur?
Stem cell definition?
Can regenerate itself
generates all cell types in that tissue
Totipotent, Pluripotent, and Multipotent stem cells?
Toti: generates all cell types and placenta (capable of forming an entire organism)
Pluri: generates all cells of organism EXCEPT for placenta
Multi: generates multiple cell types but not all
Which is toti, multi, pluri? Zygote, embryonic stell cell.
Zygote = Totipotent
ESC = Pluripotent
2 Cellular therapy for stroke?
1. Neural stem cells (NT2N and c-mycER)
2. bone-marrow derived stem cells (MPC Athersys)
Fibroblast plus 4 other genes and NANOG cause it to be transformed into induced-pluripotent stem cell