-
Phenylephrine
- Alpha-1 Agonist: vasoC
- -Tx: Shock/hypoT, nasal decongestant (neosynephrine): rhinitis medicamentosa
- -Mydriasis
- -longer t1/2 (not a stubst for COMT)
- -weak Beta effects
-
Methoxamine
- Alpha-1 Agonist: vasoC
- -Tx: Shock/HypoT
- -no Beta effect
- -longer t1/2 (not stubstr for MAO/COMT)
-
Clonidine
- Alpha-2 Agonist: AntiHT, vasoC
- -Tx: HT
- -Central SNS suppression via alpha2
- -direct vasoC via alpha1
- -Rebound HT
-
Dobutamine
- Beta-1 Agonist: inotropic, vasoD
- -Tx: CHF
- -stims Beta2 and alpha
- -inotropic via B1
- -vasoD via B2 predominates (preserves renal/GI flow)
- -may devel tolerance
-
Terbutaline
- Beta-2 Agonist: BronchoD
- Tx: Asthma/COPD
- inhalation reduces chances of Beta1 effect
- mast cell inh.
- long t1/2 (no COMT/MAO act.)
-
Albuterol
- Beta-2 Agonist: BronchoD
- Tx: Asthma/COPD
- inhalation reduces chances of Beta1 effect
- mast cell inh.
- long t1/2 (no COMT/MAO act.)
-
Amphetamine
- ^NE release
- CNS stim
- Anorexia
-
Ephedrine
- ^NE release + alpha/beta stimulation
- BronchoD
- Urinary incontinence (alpha1/beta2)
- CNS stim
- Anorexia
- contraindication w/ Caffeine
-
Metaraminol
- ^alpha1 (weak beta) + "false NT" (uptake 1: replaces NE in granules)
- Tx: Shock/hypoT
-
Phenoxybenzamine
- Alpha Antagonist: irreversible block
- Tx: Pheochromocytoma, BPH, Autonomic Hyperreflexia
- Side: Orthostatic hypoT, nasal congestion, ejaculatory dysfx
-
Phentolamine
- Alpha Antagonist:
- Tx: Pheochromocytoma, Erectile Dysfx (ED)
- equal alpha affinity
- Sides: OthroHypoT, Reflex Tachycardia (a2 block -FB), nasal congestion
-
Prazosin
- Alpha-1 Antagonist: vasoD (arterial&venous return)
- Tx: AntiHT, BPH
- "1st Dose Phenomenon": OrthoHypoT
- CNS effects possible?
-
Propranolol
- Beta Antagonist: B1=B2
- Tx: AntiHT, Ischemic Heart Disease, Hyperthyroidism, Glaucoma
- No effect on nl heart or BP at rest
- Contraindicated with Asthma/COPD (B2 blocker) & Diabetics (hypoglycemia/inh tachycardia)
- Sides: hypoglycemia, bronchC, membrane stabilizing (suppress AP's)
-
Metoprolol
- Beta-1 Antagonist:
- Tx: AntiHT, Ischemic Heart Disease
- No effect on nl heart or BP at rest
- Less likely to bronchoC
-
Guanethidine
- Sympatholytic: replaces NE in vesicles & inh vesicle release
- Tx: AntiHT (dilates arterial & venous)
- t1/2= 5 days
- Little CNS effect
- Contraindicated with MAOI's
- Sides: OrthoHypoT, GI/diarrhea, Male sexual dysfx (retrograde ejac)
-
Reserpine
- Sympatholytic: irrev inh VMAT (inh E/NE/DA uptake to vesicles), blocks NE storage/synthesis (DA-B-hydroxylase in vesicles)
- t1/2=weeks
- Tx: AntiHT, antipsychotic (rarely used)
- Sides: CNS effects (depress., sedation, suicide)
-
Methyl Tyr
- Inh Catecholamine Syn: inh Tyr Hydroxylase
- Tx: pre-op Pheochromocytoma
- Sides: SNS depression, Sedation, Anxiety
-
a-Methyldopa
- Alpha agon False NT: metab to a-methyl-NE
- Tx: AntiHT (Central SNS depression via alpha2)
- Spares renal flow
- Preferred in HT pregnancy
-
Cocaine
Uptake 1 Inh. (^NE in synaptic cleft)
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