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NSAIDS
(act by inhibiting prostaglandin synthase in particular the cyclooxygenase subunit)-which is involved in inflammation and platelet accumulation-
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Aceteminaphen,Ibuprofin-
reversible competitive inhibitors of prostaglandin synthase
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Aspirin
irreversible inhibitor of prostaglandin synthase- covalently binds to and acetylates aserine residue blocking the active site
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Vioxx(Celebrex, Bextra)-
- target COX2 enzyme which synthesizes bad prostaglandins.
- COX-2 contains a valine which is occupied by isoleucine in COX-1 … this difference allowed synthesis of a drug which can bind to the active site of COX-2 but not COX-1 and selectively inhibit COX-2 action.
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Parathion
what is it
organophosphate pesticide
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Parathion what does it do ?
- pestiside wich irreversibily inhibits acetylcholine esterase which is required for proper nervous system function.
- -Ser in A.S. forms stable phosphate esters with orangophosphates
- -acetylcholine levels increase leading to aberrant nervous system signaling,
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parathion symptoms
-paralysis of the respiratory muscles and pulmonary adema
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parathion treatment
atropine which interferes with the binding of acetylcholine to its receptor relieving the symptoms
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viagra (cialis, levitra)
relatively specific cGMP-phosphodiesterase inhibitor which results in cGMP levels remaining elevated for longer following NO release and blood vessels remain relaxed with increased blood flow
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nitrogylcerin-
converted to No in teh body andi s used to treat angina. increase No relaxes blood vessels makes the workload and oxygen requirement of heart to go down.
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digitalis
family of cardiotonic steroids which inibitit Na/K pump which increases contractile force of the heart and slow rate of beating (purple foxglove)
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tubocurarin
- inhibits nicotinic acetylcholine receptor
- found in curare arrow poison used by south american tribes in plants
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alpha neurotoxins
- cause paralysis by blocking nicotinic acetylcholine receptor
- produced by cobra toxin bungarotoxin, and conotoxin
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