Patho 3

What percent of ATP depletion leads to changes in neurologic cortical signs? (p.1)

55% ATP depletion
Neurological cortical signs
(5)
- speech
- behavior
- memory
- judgment
- personality
At what temperature does brain cell death occur due to ATP depletion? (p.3)

106 degrees Fahrenheit
In terms of time frame, when does a seizure become a medical emergency? (p.3)
- 20-30 minutes
- rapid ATP depletion
Review changes in blood flow during a seizure (increased or decreased). (p.2)
- Seizure activity = rapid ATP depletion
- Increase in CBF 250-300% to meet metabolic demands of seizure activity
What is the primary energy source for brain function? (p.1)

Glucose - converted to ATP
What effect does increase in BP have on diameter of cerebral arteries? (p.6)
- Vasoconstriction
- Increase systemic arterial pressure or ICP
- Prevents hyperemic flow state
What effect does decreased BP have on the diameter of cerebral arteries? (p.6)
- Vasodilation
- Protects brain from subflow state and subsequent infarction
Metabolic factors affecting brain's ability to auto-regulate. (p.7)
- Increased PaCO2
- Decreased PaO2
- Brain injury
- Intracranial bleeding
Pressure changes affecting brain's ability to auto-regulate (p.7)
- Cerebral vasodilatory drugs
- Change in MAP
- Increased ICP >35 mmHg longer than 20-30 minutes
- Change in CPP
MAP formula
(p.8)
CPP formula
(p.8)
Normal CPP range

50 - 150 mmHg
Average CPP

80 - 100 mmHg
CPP < 50

Ischemia
CPP > 150

Hyperemia
CPP < 30

Incompatible with life

Author

cgordon05

16685

Card Set

Patho 3

Description

Neuro

Updated

2010-04-29T00:23:16Z

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