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Parkinson's disease

  1. Pathoohysiology?
    • - Progressive chronic neurological disorder.
    • - May develop @ any age- most common in 60s.
    • - No cure for disease.
    • - Therapy aimed at controlling symptoms. 
    • - Signs and symptoms relate to damaged neurons in the basal ganglia of the brain.
  2. Theories of causes?
    • -Viral infection.
    • - Blows to the head.
    • - Brain infection.
    • - Atheroslerosis.
    • - Exposure to drugs and environmental factors.
  3. Causes of signs and sypmtoms?
    In substantia nigra, a dopamine-rich area in the brain, nerve cell bodies begin to degenerate, resulting in a reduction of the number of impulses sent to the corpus striation in the basal ganglia.
  4. Signs and symptoms of Parkinson's?
    • - TRAP
    •    -Tremors
    •    -Rigidity
    •    -Bradykinesia
    •    -Position/ Posture
    • -Lack of coordination.
    • - Mask-like expression.
    • - Problem walking 
    • - Drooling and affected speech. 
  5. Treatment? 
    • Levodopa (Dopar)
    • - Antiparkinsonian
    • - Dopaminergic Agent 
    • Sinemet (Carbidopa-Levodopa)
    • - Dopaminergic Agent
  6. Secondary symptoms of Parkinson's Disease?
    • - Depression.
    • - Sleep disturbances
    • - Dementia
    • - Forced eyelid closure
    • - Drooling, dysphagia, constipation
    • - Shortness of breath.
    • - Urinary hesitancy and urgency.
    • - Decreased sex drive.
  7. Sinemet?
    • Carbidopa-Levodopa
    • Act: carbidopa is an enzyme inhibitor which reduces the metabolism of levodopa
  8. Therapeutic O/C for sinemet?
    • -Dopamine agonist.
    • -Establish a balance of dopamine and acetylcholine in the basal ganglia. Enhances delivery of dopamine to brain cells
Author
kawally
ID
166580
Card Set
Parkinson's disease
Description
Sign and symptoms
Updated

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