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What is the most common translocation and chimeric genes/fusion proteins associated with chronic myelogenous leukemia?
-- t(9;22)(q34q11), BCR/ABL
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What is the most common translocation and chimeric genes/fusion proteins associated with acute myeloid leukemia?
-- t(8;21)(q22;q22), AML1/ETO
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What is the most common translocation and chimeric genes/fusion proteins associated with acute promyelocytic leukemia?
-- t(15;17)(q22;q12), PML/RAR αlpha
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What is the most common translocation and chimeric genes/fusion proteins associated with AML with abnormal eosinophils?
-- t(16;16)(p13;q22) [or inv(16)(p13q22)], CBFb/MYH11
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What is the most common translocation and chimeric genes/fusion proteins associated with Burkitt lymphoma?
-- t(8;14)(q24;q32), c-MYC/Ig heavy chain locus
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What are the 4 most common translocations and chimeric genes/fusion proteins associated with precursor B ALL?
- -- t(9;22)(q34;q11.2), BCR/ABL
- -- t(4;11)(q21;q23), AF4/MLL
- -- t(1;19)(q23;p13.3), PBX/E2A
- -- t(12;21)(p13;q22), TEL/AML1
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What is the most common translocation and chimeric genes/fusion proteins associated with mantle cell lymphoma (involves virutally all cases)?
-- t(11;14)(q13;q32), Ig heavy chain locus/BCL1
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What is the most common translocation and chimeric genes/fusion proteins associated with follicular lymphoma?
-- t(14;18)(q32;q21), BCL2 rearranged
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What is the most common translocation and chimeric genes/fusion proteins associated with MALT lymphoma?
-- t(11;18)(q21;q21), API2/MLT
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What is the most common translocation and chimeric genes/fusion proteins associated with anaplastic large cell lymphoma?
-- t(2;5)(p23;q35), ALK/NPM
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What is the most common translocation and chimeric genes/fusion proteins associated with T cell prolymphocytic leukemia?
-- t(14;14)(q11;q32) [or inv14q(q11;q32)], TCR α/TCL1
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What is the most common translocation and chimeric genes/fusion proteins associated with alveolar soft part sarcoma?
-- t(X;17)(p11;q25), TFE3-ASPL
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What are the 2 most common translocations and chimeric genes/fusion proteins associated with alveolar rhabdomyosarcoma?
- -- t(2;13)(q35;q14), PAX3/FKHR
- -- t(1;13)(q36;q14), PAX7-FOXO1A
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Which resulting chimeric gene has a relatively more favorable outcome in alveolar rhabdomyosarcoma?
-- PAX7-HKHR has a favorable prognosis (over PAX3-FKHR) ("seventh heaven")
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What is the most common translocation and chimeric genes/fusion proteins associated with congenital fibrosarcoma?
-- t(12;15)(p13;q25), ETV6/NTRK3
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What are the 2 most common translocations and chimeric genes/fusion proteins associated with clear cell sarcoma?
- -- t(12;22)(q13;q12), EWSR1-ATF1
- -- t(2;22)(q33;q12), EWSR1-CREB1
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What is the most common translocation and chimeric genes/fusion proteins associated with dermatofibrosarcoma protuberans?
-- t(17;22)(q22;q13), COLIA1/PDGFB (>95%)
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What are the 2 translocations and chimeric genes/fusion proteins associated with desmoplastic small round cell tumor?
- -- t(11;22)(p13q;12), EWS/WT1
- -- t(21;22)(q22;q12), EWSR1-ERG
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What are the 2 most common genetic aberrations (translocation and chimeric genes/fusion) proteins associated with Ewing's sarcoma/PNET?
- -- t(11;22)(q24;q12), EWS/FLI1 (90%)
- -- t(21;22)(q22;q12), EWS-ERG( 5%)
- -- (there are several other rare translocations and other aberrations)
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What is the most common translocation and chimeric genes/fusion proteins associated with malignant melanoma of soft parts/clear cell sarcoma?
-- t(12;22)(q13;q12), EWS/ATF1 (>85%)
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What is the most common translocation and chimeric genes/fusion proteins associated with myxoid/round cell liposarcoma?
- -- t(12;16)(q13;p11), TLS/CHOP (95%)
- -- [t(12;22)(q13;q12), EWS-CHOP (5%)]
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What is the most common translocation and chimeric genes/fusion proteins associated with synovial sarcoma?
-- t(X;18)(p11.23;q11), SYT/SSX1 [or t(X;18)(p11;q11), SS18-SSX2]
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What are the 2 translocations and chimeric genes/fusion proteins associated with papillary renal cell carcinoma?
- -- t(X;1)(p11;q21), TFE3/PRCC
- -- t(X;1)(p11;p34), TFE3/PSF
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2 protooncogenes, RET and NTRK1 may be fused to the amino-terminus of many different gene products in what type of cancer?
-- Papillary thyroid carcinoma
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Deletion of TMPRSS2 with fusion to ETS family proteins (ERG, ETV1, or ETV4) may be seen in what type of cancer?
-- Prostate cancer
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What is the most common translocation and chimeric genes/fusion proteins associated with follicular thyroid carcinoma?
-- t(2;3)(q13;p25), PAX8-PPARγ
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What are the most common molecular targets in glioblastoma?
-- del 10q, EGFR, TP53, PTEN, MGMT
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What are the most common molecular targets in oligodendroglioma?
-- del 1p and 19q, EGFR, TP53
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What is the most common genetic alteration in sporadic, non-hereditary breast cancer?
-- HER2/neu
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What are the most common molecular targets in hereditary breast cancer?
-- BRCA1, BRCA2, EGFR
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What are the most common molecular targets in papillary thyroid carcinoma?
-- BRAF, RET, PTC1, PTC3
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What are the 2 most common genetic aberrations in follicular thyroid carcinoma?
- -- t(2;3)(q13;p25), PAX8-PPARy
- -- RAS mutations
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What is the most common molecular target in medullary thyroid carcinoma?
-- RET
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What are the most common molecular targets in non-small cell carcinomas of the lung?
-- EGFR, RAS
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What is the most common genetic aberration and associated genes in desmoplastic small round cell tumor?
-- t(11;22)(p13;q12), EWS-WT1 (> 80%)
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Gains and losses of multiple chromosomes, and aberrations in IGF2, GOK, PTCH, and p53 are associated with what neoplasm?
-- Embryonal rhabdomyosarcoma
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What are the two most common translocations and genes associated with alveolar rhabdomyosarcoma?
- -- t(2;13)(q35;q14), PAX3-FKHR (75%)
- -- t(1;13)(p36;q14), PAX7-FKHR (10%)
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What are the most common genetic aberrations and involved genes associated with synovial sarcoma?
-- t (X;18)(p11;q11); SYT-SSX1 (65%), SYT-SSX2 (35%), or SYT-SSX4 (rare)
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What is the most common genetic aberration and involved gene associated with infantile fibrosarcoma?
-- t(12;15)(p13;q25), ETV6-NTRK3 (~100%)
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What is the most common genetic aberration and involved gene associated with inflammatory myofibroblastic tumor?
-- Rearrangements of 2p23, ALK (50%)
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What is the most common genetic aberration and involved genes in angiomatoid fibrous histiocytoma?
-- t(12;16)(q13;p11), TLS-ATF1
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What is the most common genetic aberration and involved genes in low-grade fibromyxoid sarcoma?
-- t(7;16)(q34;p11), TLS-CREB3L2
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Activating mutations in what 2 genes are associated with NON-gastrointestinal soft tissue stromal tumors?
-- c-kit, PDGFRA
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What 3 tumor types can harbor ETV6-NTRK3 fusion genes in >90% of cases?
- -- Infantile fibrosarcoma
- -- Mesoblastic nephroma (cellular and mixed types)
- -- Secretory carcinoma of breast
- -- [Rarely, AML can have this fusion also]
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Inflammatory myofibroblastic tumor often involves fusion between what gene and several other partners?
-- ALK
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Lipomas are associated with rearrangements involving what two genes?
-- HMGA2 and HMGA1
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What is the most common genetic aberration and involved genes in hibernoma?
-- 11q13 rearrangements; MEN1, PPP1A
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What translocation is associated with chondroid lipoma?
-- t(11;16)(q13;P12-13)
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Spindle cell/pleomorphic lipomas involve deletions of what two chromosomes?
-- del 16q13, del 13q
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What genetic translocation is associated with epithelioid hemangioendothelioma?
-- t(1;3)(p36.3;q25)
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