1. absorption
    the process of movement of a drug from the site of administration into the systemic circulation
  2. acetylation
    a conjugation reaction involving the hepatic enzyme acetyle transferase, which metabolizes the inactivates amines, hydrazines, and sulfonamindes
  3. adsorption
    the adhesion of drug molecules to the surface of another substance by physical or chemical attraction
  4. bioavailability
    the degree to which a drug or other substance reaches the general circulation and becomes available to the target organ or tissue
  5. biotransformation
    the metabolism of drugs by reactions such as oxidation, reduction, hydrolysis, or conjugation
  6. black box warning
    the most serious warning required by the Food and Drug Administration on drug labels; such warnings appear in a box surrounded by a black border at the beginning of the label information
  7. cytochrome P-450 enzyme system
    a multienzyme system in the smooth endoplasmic reticulum of numerous tissues that is involved in phase I of liver detoxification and is the major catalyst of drug biotransformation reactions
  8. drug-nutrient interaction
    the result of the action between a drug and a nutrient that would not happen with the nutrient or the drug alone
  9. excipient
    substance added to a drug, such as a buffer, binder, filler, diluent, disintegrant, glidant, flavoring, dye, preservative, suspending agent, or coating; also called inactive ingredient
  10. food-drug interaction
    a broad term that includes drug-nutrient interactions and the effect of a medication on nutritional status
  11. half-life
    the amount of time it takes for the blood concentration of a drug to decrease by one--half its steady-state level
  12. pharmacodynamics
    the study of the physiologic and biochemical effects of a drug or combination of drugs
  13. pharmacogenomics
    the study of genetically determined variations that are revealed solely by the effects of drugs in the body
  14. pharmacokinetics
    the movement of a drug through the body by absorption, distribution, metabolism, and excretion
  15. physical incompatibility
    a food-drug interaction involving granulation, gel formation, or separation of the enteral nutritional product when food and drug are combined
  16. polypharmacy
    the use of multiple drugs to treat one or more health conditions
  17. pressor agents
    organic compounds, including tyramine, dopamine, phenylethylamine, and histamine, that cause vasoconstriction and an increase in blood pressure
  18. side effect
    adverse effect, reaction, or any undesirable outcome of a drug
  19. unbound fraction
    the amount of a drug that is not bound to serum proteins, is able to leave the vasculature, and produces a pharmacologic effect at a target organ

    (vasculature: arrangement of blood vessels in the body)
Card Set
Assessment: Food-Drug Interactions