-
Alanine
Ala
- non polar
- aliphatic
- hydrophobic
-
- non polar
- aliphatic
- hydrophobic
-
glycine
Gy
- only one with asymmetric alpha carbon
- no beta carbon
- nonpolar
- aliphatic
- hydrophobic
-
isoleucine
Ile
- non polar
- aliphatic
- hydrophobic
-
leucine
Leu
- non polar
- aliphatic
- hydrophobic
-
- non polar
- aliphatic
- hydrophobic
- restricts conformations
-
methionine
met
- non polar
- aliphatic
- hydrophobic
-
phenyalanine
Phe
- aromatic
- hydrophobic
- often interior of water soluble proteins
-
- Aromatic
- Slightly polar
- Phosphate acceptors in protein tyrosine kinase rxs
- Protein surfaces
-
- aromatic
- hydrophobic
- often interior
- slightly polar
-
Serine
Ser
- Polar
- Uncharged
- Int and ext
- H+ bond -important for structure
- Often serve as phosphate acceptors in protein serine kinase rxs
-
- Polar
- Uncharged
- Int and ext
- H+ bond -important for structure
- Oftenserve as phosphate acceptors in protein serine kinase rxs
-
- polar
- uncharged
- int and ext
- H+ bonds important in structure
-
- Polar
- Uncharged
- Int and ext
- H+ bond -important for structure
- Disulfide bridges with other –SH
- Dimer called cysteine – often in protein structure crosslinks polypeptide chains
-
- polar
- uncharged
- int and ext
- H+ bonds important in structure
-
- ionizable side chain
- carboxyl side chain
- Acidic
- negatively charged
- deprotonated at pH = 7
-
- ionizable side chain
- carboxyl side chain
- Acidic
- negatively charged
- deprotonated at pH = 7
-
- ionizable side chain
- basic
- positively charged
- proton acceptors
- protonation state will define net charge at given pH
-
- ionizable side chain
- basic
- positively charged
- proton acceptors
- protonation state will define net charge at given pH
-
- ionizable side chain
- basic
- positively charged
- proton acceptors
- protonation state will define net charge at given pH
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