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Homeostatsis
body conditions close to normal
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homeostatic mechanisms
control actions to prevent dangerous conditions in the body
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water is the most common substance in the body
what % is the total body weight in a healthy young adult and what % is the total body weight in a healthy older adult
- 55%-60% young adult
- 50%-55% older adult
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ecf (extracellular fluid)
fluid outside the cells; 1/3 (15 l) of total body water
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icf (Intracellular fluid)
fluid inside the cells; 2/3 (25 l) of total body water
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interstitial fluid
fluid between cells, blood, lymph, bone, connective tissue water and transcellular fluids
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transcellular fluids
includes cerebrospinal fluid, synovial fluid, peritoneal fluid, and pleural fluid
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solvent
water portion of fluids
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solutes
the particles dissolved or suspended in water (solvent)
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electolytes
solutes that have an electrical charge
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3 processes that control fluid and electrolyte balance
filtration, diffusion, and osmosis. They determine how, when, and where fluids and particles move across the cell membrane
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filtration
movement of fluid thru a cell or blood vessel membrane because of hydrostatic pressure differences on both sides of the memebrane
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hydrostatic pressure
pressing of water molecules. "water-pushing" pressure. Is what pushes water outward from a confined space thru the membrane
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viscous
thick as in blood is thicker than water
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permeable
porous membrane
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equilibrium
when hydrostatic pressure is the same in both fluid spaces, no difference in hydrostatic pressure
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disequilibrium
hydrostatic pressure is not the same in both spaces
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gradient
graded difference b/w two spaces... one has a high hydrostatic pressure whereas the other has a low
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filters
water moving thru a membrane with nothing stopping it
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example of hydrostatic filtering force
blood pressure
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edema
- tissue swelling with fluid collection... can occur with right sided heart failure
- *excess filtration of fluid from the capillaries into the interstitial tissue space occurs, forming visible edema
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diffusion
the free movement of particles (solute) across a permeable membrane from an area of higher concentration to an area of lower concentration (down a concentration gradient)
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concentration gradient exists when:
two fluid spaces have different amounts of the same type of particles
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impermeable
membrane that is not open (no pores)
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facilitated diffusion or facilitated transport
a form of diffusion across a cell membrane that requires the assistance of a membrane-altering system (for ex insulin)
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osmosis
- the movement of water only thru a selectively permeable (semipermeable) membrane
- (usually water can always move thru a cell membrane)
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osmolarity
the number of milliosmoles in a liter of solution
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Osmolality
the number of milliosmoles in a kilogram of solution
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Isosmotic (aka isotonic or normotonic)
- when all body fluids have 300 MOSM/L PARTICLE CONCENTRATION THE BODY FUNCTIONS AT ITS BEST
- NORMAL RANGE IS 270-300 MOSM/L
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HYPEROSMOTIC (AKA HYPERTONIC)
- FLUID OSMOLARITIES ARE GREATER THAN 300 MOSM/L
- HAVE A GREATER OSMOTIC PRESSURE THAN ISOSMOTIC FLUIDS
- PULLS WATER FROM THE ISOSMOTIC FLUID SPACE INTO THE HYPEROSMOTIC FLUID SPACE UNTIL BALANCE OCCURS
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HYPO-OSMOTIC (AKA HYPOTONIC)
- FLUID OSMOLARITIES OF LESS THAN 270 MOSM/L
- HAVE A LOWER OSMOTIC PRESSURE THAN ISOSMOTIC FLUIDS
- WATER IS PULLED FROM THE HYPO-OSMOTIC FLUID SPACE INTO THE ISOSMOTIC FLUID SPACE
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SOLUBILITY
- HOW WELL A PARTICLE TYPE WILL DISSOLVE IN WATER
- THE MORE SOLUBILITY OF A PARTICLE THE HIGHER THE OSMOTIC PRESSURE
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osmoreceptors
cells sensitive to changes in ECF osmolarity
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average fluid intake by an adult of liquids:
fluid intake from solid foods:
- Liquids: 1500 ml
- Solid Foods: 800 ml
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obligatory urine output
minimum amount of urine per day needed to excrete toxic waste products is 400 to 600 ml
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Ways fluid loss occurs:
- Kidney's (most important and sensitive)
- skin
- lungs
- intestinal tract
- salivation
- drainage from fistulas and drains
- Gi suction
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In healthy adult insensible water loss is about ____ ml per day
500-1000 ml/day
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aldosterone prevents both ___ and ___ loss
water and sodium
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most important fluids to keep in balance are:
- blood volume (plasma volume) *most critical in preventing death (keeps blood pressure high enough to ensure perfusion and oxygenation of all organs and tissues)
- fluid inside the cells (intracellular fluid)
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Kidneys monitor
blood pressure, blood volume, blood oxygen levels, and blood osmolarity (r/t NA concentration)
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impermeable cell membrane
not open to certain particles
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facilitated diffusion or facilitated transport:
diffusion across a cell membrane that requires the assistance of a membrane-altering system (ex: insulin- helps glucose cross cell membrane)
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osmosis
movement of water only thru a selectively permeable (semipermeable) membrane
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causes the kidney to reabsorb water and sodium
aldosterone
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renin activates ____
angiotensin 1
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angiotensin 1 activates
angiotensin-converting enzyme (ace) which turns angi 1 into angiotensin 2
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angiotensin 2 works to:
- increase blood volume and blood pressure
- By:
- 1.constriction of small arteries and veins
- 2.constricts the size of the arterioles that feed the kidney nephrons
- 3.cause adrenal glands to secrete aldosterone (last and slower action)
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dehydration
- fluid intake or fluid retention is less than what is needed to meet the body's fluid needs
- condition rather than a disease
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relative dehydration
when water shifts from the plasma into the interstitial space
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isotonic dehydration
- water and electrolyte loss
- most common type of fluid loss problem
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hypovolemia
blood volume is decreased (leads to inadequate tissue perfusion)
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"ortho checks" or "Ortho changes"
measure of blood pressure lying down, sitting, then standing
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hemoconcentration
when more water is lost and other substances remain increasing osmolarity or concentration of the blood
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two most important areas to monitor during rehydration are
pulse rate and quality and urine output
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antimicrobial therapy
drug therapy used in patients with bacterial diarrhea to stop dehydration
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antiemetics
drug therapy used when vomiting causes dehydration
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antipyretics
drug therapy used to reduce a fever that may cause dehydration to worsen
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fluid overload
- excess of body fluid
- not a disease; a clinical sign of a problem where fluid intake or retention is greater than the body's fluid needs
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hypervolemia
most common fluid overload
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hemodilution
- excessive water in the vascular space causing decreased hemoglobin, hematocrit, and serum protein levels
- serum electrolyte values usually normal
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indicators of increased fluid overload:
- bounding pulse
- increasing neck vein distention
- presence of crackles in the lungs
- increasing peripheral edema
- reduced urine output
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diuretics
- drug therapy used for fluid overload as long as kidney failure is not the cause
- increase kidney water or sodium excretion
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specific gravity below 1.005 may indicate:
fluid overload
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electrolytes (ions)
substances in body fluids that carry an electrical charge
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cations
positively charged electrolytes
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anions
negatively charged electrolytes
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