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What are the functions of the nervous system?
Receive external stimuli that activate the cell membrane of nerve cells to release nervous impulses, carry impulses to and from the brain and spinal cord, recognize, interpret, and relay impulses to other nerve cells that extend throughout the body
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Cranial nerve I
olfactory - smell
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Cranial nerve II
optic -vision
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Cranial nerve III
Oculomotor - eye movement
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Cranial nerve IV
trochlear - eye movement
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Cranial nerve V
Trigeminal - forehead and scalp sensation, cheek sensation, and chewing
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Cranial nerve VI
Abducens - Eye movement
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Cranial nerve VII
facial - face and scalp movement, taste, ear sensation
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Cranial nerve VIII
Vestibulocochlear - hearing and balance
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Cranial nerve IX
Glossopharyngeal - tongue and throat sensations and throat movements
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Cranial nerve X
Vagus nerve - messages to and from neck, chest, abdomen - peristalsis, blood pressure, heart rate, coughing, sneezing
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Cranial nerve XI
Accessory - swallowing and head and should movements
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Cranial nerve XII
Hypoglossal - speech and swallowing
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What does the sympathetic nervous system do?
increase heart rate and forcefulness, dilate airways, increase blood pressure, stimulate the adrenal gland to secrete epinephrine, and inhibit intestinal contractions
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What does the parasympathtic nervous system do?
Decrease heart rate, lower blood pressure, stimulate intestinal contractions
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What is white matter?
Composed of cell bodies covered with myelin sheath
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What is gray matter?
Composed of cell bodies of neurons not covered with myelin sheaath
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Afferent nerve
Carry impulses to the brain and spinal cord from stimulus receptors
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Efferent nerve
Carry impulses away from the CNS to organs that produce responses
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What is the function of astrocytes?
Transport water and salts between capillaries and neurons
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What is the function of microglial cells?
phagocytic glial cells that remove waste products from the CNS and protect neurons in response to inflammation
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What is the function of Oligodendroglial cells?
Form the myelin sheath in the CNS
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What is the function of ependymal cells?
Line membranes within the brain and spinal cord where cerebrospinal fluid circulates; helps form cerebrospinal fluid
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What region of the brain is the gray matter?
Outermost layer; cerebral cortex
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What is the right half of the brain responsible for?
Spatial relationships, art, music, emotions, and intuition
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What is the left half of the brain responsible for?
Language, math functioning, reasoning, and analytical thinking
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Function of Cerebrum
Thought, judgment, memory association, and discrimination
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Function of Thalamus
Main relay center of the brain, conducts impulses between the spinal cord and cerebrum; decides what information is important and maintains levels of awareness and consciousness
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Function of Hypothalamus
Body temperature, sleep, appetite, sexual desire, and emotions; regulates release of hormones from the pituitary gland, integrates activities of the sympathetic and parasympathetic nervous system
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Function of Cerebellum
Voluntary muscle movements and maintains balance and posture
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Function of Basal ganglia
Regulate intentional movements of the body
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Function of Medulla oblongata
Respiratory center - controls muscles of respiration, cardiac center - slows the heart rate when it is beating too rapidly, vasomotor center - affect the muscles in the walls of blood vessels
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Frontal lobe
Thought processes, behavior, personality, and emotion (Broca area - language expression)
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Parietal lobe
Body sensations, visual and spatial perception
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Temporal lobe
Hearing, understanding speech and language (Wernicke area - language comprehension)
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Where is the wernicke area and what is its function?
temporal lobe of cerebrum - language comprehension
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Where is the broca area and what is its function?
Frontal lobe of cerebrum - language expression
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Where is the gray matter of the spinal cord?
inner region
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Where is the white matter of the spinal cord?
Outer region
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Where is the gray matter of the brain?
Outer region (cerebral cortex)
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Where is the white matter of the brain?
Inner region
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Alges/o
Excessive sensitivity to pain
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Esthesi/o
Feeling, nervous sensation
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Syncop/o
To cut off, cut short
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-algesia
Excessive sensitivity to pain
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-esthesia
Feeling, nervous sensation
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Afferent nerve
Nerve that carries nervous impulse toward the brain and spinal cord; sensory nerves
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Akinetic
Pertaining to loss or absence of voluntary movement
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Amyloid
Deposit of proteins in neurofibrillary tangles
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Amyotrophic lateral sclerosis (Lou Gehrig disease)
Degenerative disorder of motor neurons in the spinal cord and brain stem
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What do tonic and clonic mean?
tonic - stiffening of muscles, clonic - twitching and jerking movements of limbs
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Temporal lobe epilepsy
Seizures begin in temporal lobe of the brain
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Complex partial seizure
Mostcommon type of seizure - pause in whatever they are doing, confusion, and memory problems
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Analgesia
Absence of sensitivity to pain
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Anencephaly
Congenital condition of partial or complete absence of brain matter
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Anesthesia
Lack of feeling or sensation
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Anesthetics
Agents that reduce or eliminate sensation
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Aphasia
Inability to speak; language function is impaired due to injury to the cerebral cortex
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Alzheimer disease
Brain disorder marked by gradual and progressive mental deterioration, personality changes, and impairment of daily functioning
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Which chromosome is linked to AD?
Chromosome 14
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What are 3 characteristics of AD?
Senile plaques (degeneration of neurons), neurofibrillary tangles (bundles of fibrils in the cytoplasm of a neuron) in the cerebral cortex, amyloid deposits
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Apraxia
Inability to perform purposeful acts or manipulate objects
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Arachnoid membrane
Middle layer of meninges covering brain and spinal cord
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Astrocyte
Glial cell that transports salts and water from capillaries
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Ataxia
Without coordination
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Basal ganglia
Regulate intentional movements of the body
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Bell palsy
Paralysis on one side of the face caused by a viral infection
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Cerebellopontine
Pertaining to the cerebellum and pons
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Cerebellum
Part of the brain that coordinates muscle movements and maintains balance
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Cerebral concussion
Temporary brain dysfunction after injury; usually clearing within 24 hours
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Cerebral contusion
Bruising of brain tissue as a result of direct trauma to the head; neurologic disorder persists longer than 24 hours
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Cerebral palsy
Partial paralysis and muscular coordination caused by loss of oxygen or blood flow to the cerebrum during pregnancy or in the perinatal period
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Cerebrospinal fluid analysis
Samples of CSF are examined for blood cells, protein, glucose, tumor cells, bacteria, and other substances
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Cerebrum
Largest part of the brain; responsible for voluntary muscular activity, vision, speech, taste, hearing, thought, memory, and other functions
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Coma
State of unconsciousness from which a patient cannot be aroused
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Corpus callosum
Center portion of the brain that connects the two hemispheres
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Dopamine
Neurotransmitter in CNS made by cells in the basal ganglia
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Doppler/ultrasound studies
Sound waves are used to detect blood flow in arteries within the brain and leading to the brain
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Dyskinesia
Impairment of the ability to perform voluntary movements
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Dyslexia
Difficulty in reading, writing, and learning
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Efferent nerve
Nerve that carries message away from the brain and spinal cord; motor nerve
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Ependymal cell
Glial cell that lines the membrane within the brain and spinal cord and helps form cerebrospinal fluid
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Epidural hematoma
Collection of blood located between the skull and dura mater due to ruptured meningeal artery (usually after a skull fracture)
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Epilepsy
Brain disorder marked by recurrent attacks of abnormal nervous impulses
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Glioblastoma
Rapidly growing malignant tumor of the brain
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Gray matter
Region of brain and spinal cord containing cell bodies and dendrites
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Gyrus
Sheet of nerve cells that produce a rounded fold on the surface of the cerebrum
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Herpes zoster
Viral infection affecting peripheral nerves
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Huntington Disease
Hereditary disorder affecting the cerebrum (degenerative changes in cerebrum) and involving abrupt, involuntary, jerking movements, and mental deterioration in later stages
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What causes Huntington Disease?
Hereditary - genetic defect on chromosome 4
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What causes MS?
idiopathic - maybe autoimmune disease of lymphocytes reacting against myelin
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Hypalgesia
Diminished sensitivity to pain
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Hyperesthesia
Excessive sensitivity or feeling especially of the skin in response to touch or pain
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Hypothalamus
Portion of the brain beneath the thalamus; controls sleep, appetite, body temperature, and secretions from the pituitary gland
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Ictal event
Pertaining to a sudden, acute onset, as the convulsion of an epileptic seizure
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Intracerebral hematoma
Collection of blood within the cerebrum due to bleeding in the brain tissue (usually from uncontrolled hypertension)
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Intrathecal
Pertaining to within the membranes surrounding the brain and spinal cord
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intrathecal injections
Chemicals injected into the subarachnoid space
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Irreversible coma
Brain death; complete unresponsitivity to stimuli, no spontaneous breathing or movement, and a flat EEG tracing
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Leptomeningitis
Inflammation of the two thinner membrane surrounding the brain and spinal cord
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Lumbar puncture
Withdrawal of cerebrospinal fluid from the subarachnoid space between two lumbar vertebrae; spinal tap
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Medulla oblongata
Lower part of the brain, closest to the spinal cord; controls breathing, heartbeat, and size of blood vessels
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Meningocele
Hernia in the meninges through a defect or space between vertebrae; a form of spina bifida cystica
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Microglial cell
Phagocytic glial cell that removes waste products from the central nervous system
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Motor aphasia
Broca aphasia; expressive aphasia; The patient knows what he wants to say but cannot say it
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Myasthenia gravis
Autoimmune neuromuscular disorder characterized by weakness of voluntary muscles
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What causes MG?
Antibodies block the ability of acetylcholine to transmit the nervous impulse from nerve to muscle cell
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What treatments are used for MS?
Corticosteroids to reduce inflammation, interferons to slow the rate of MS symptoms, Glatiramer to block immune system's attack on myelin
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What treatments are used for MG? Therapy, Anticholinesterase drugs inhibit the enzyme that breaks dwon acetylcholine, corticosteroids, immunosuppressive drugs, thymectomy
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Myelomeningocele
Congenital hernia of the spinal cord and meninges through a defect in the vertebral column; associated with spina bifida
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Neurasthenia
Lack of strength in the nerves; feeling of weakness and exhaustion
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Neuroglia
Supporting cells of the nervous system
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Oligodendroglial cell
Glial cell that forms the myelin sheath covering the axon of a neuron
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Paresthesia
Abnormal nervous sensation occurring without apparent cause; tingling, numbness or pricking sensations
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Parkinson Disease
Degeneration of nerves in the basal ganglia occur in later life, leading to tumors, shuffling gait, and muscle stiffness; dopamine is deficient in the brain
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What causes parkinson disease?
Deficiency of dopamine
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How is parkinson disease treated?
Levodopa + carbidopa (sinement) to increase dopamine levels in the brain to relieve symptoms
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what causes tourette syndrome?
idiopathic; associated with excess of dopamine or hypersensitivity to dopamine
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What are treatments for tourette syndrome?
Antipsychotic drugs, antidepressants, and mood stabilizers
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How is meningitis diagnosed and treated?
Lumbar puncture to examine CSF for diagnosis and antibiotics and antivirals for treatment
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What are three types of CVA?
Thrombotic - blood clot in the arteries leading to the brain that blocks the vessels (TIAs), embolic - embolus occludes small cerebral vessel, 3.Hemorrhagic - blood vessel breaks and bleeding occurs
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How is CVA treated?
tPA within 3 hours of stroke onset and surgical intervention with carotid endarterectomy
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What causes a migraine?
Dilation of blood vessels
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Gamma knife
High-energy radiation beam used to treat deep and inaccessible intracranial brain tumors and abnormal blood vessel masses
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Proton sterostatic radiosurgery
Delivers uniform dose of protom radiation to target and spares surrounding tissue
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Poliomyelitis
Inflammation of the gray matter of the spinal cord
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Pons
Part of the brainstem anterior to the cerebellum, between the medulla and the rest of the brain; connects the upper and lower portions of the brain
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Postictal events
Neurologic symptoms such as weakness after seizures
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Radiculitis
Inflammation of a spinal nerve root
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Radiculopathy
Disease of a spinal nerve root
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Semicomatose
A stupor (unresponsiveness) from which a patient can be aroused.
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Sensory aphasia
The patient articulates words easily but uses them inappropriately; difficulty understanding written and verbal commands and cannot repeat them
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Spina bifida
Congenital defect in the lumbar spinal column caused by imperfect union of vertebral parts; spinal and meninges may herniate through the vertebral gap
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Spina bififa occulta
Vertebral defect is covered with skin and evident onliny in x-rays
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Spina bifida cystica
More severe form with cyst-like protrusions
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Meningocele
Meninges protruse to the outside of the body
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Myelomeningocele
Spinal cord and meninges protrude
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How is spina bifida diagnosed?
Prental imaging methods and testing maternal blood samples for AFP
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Stereostatic radiosurgery
Use of a specialized instrument using three-dimensional coordinates to locate the site to be operated on
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Subarachnoid space
Space between the pia mater and arachnoid membrane that controls CSF
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Subdural hematoma
Collection of blood in the space below the dura mater from tearing of veins between the dura and arachnoid membranes
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Sulcus
Depression or groove in the surface of the cerebral cortex; fissure
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Transient ischemic attach
Fleeting episode of ischemia in the brain
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Trigeminal neuralgia
Flashes of stab like pain along the course of a branch of the trigeminal nerve; trigeminal nerve has branches to the eye, upper and lower jaw
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Vagus nerve
Tenth cranial nerve that controls the chest and abdominal organs
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Ventricles
Fluid-filled canals in the brain
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White matter
Region of brain and spinal cord containing nerve fiber tracts with myelin sheath
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TLE
Temporal lob epilepsy
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TIA
Transient ischemic attack
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AVM
Arteriovenous malformation; congenital tangle of arteries and veins in the cerebrum
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TBI
Traumatic brain injury
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CVA
Cerebrovascular accident
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PSRS
Proton stereotactic radiosurgery
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GABA
Gamma-amniobutyric acid (neurotransmitter)
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ICP
Intracranial pressure (normal = 5-15 mm Hg)
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MAC
Monitored anesthetic care
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TENS
Transcutaneous electrical nerve stimulation; technique using a battery-powered device to relive acute and chronic pain
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What is the cause of hydrocephalus?
Impaired circulation of CSF in the brain or spinal cord at birth; brain tumor or infection in adults
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How is hydrocephalus treated?
Catheter placed in the ventricle of the brain into the peritoneal space or right atrium of the heart to drain CSF from the brain
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