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Which types of anemia cause MACROcytic (Megaloblastic) morphology?
- Megaloblastic anemia
- Folic Acid deficiency
- Vit B12 deficiency/Pernicious Anemia
*RNA/DNA synthesis impeded, therefore cell divison is skipped resulting in abnormally large cells!
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Which causes normochromic, normocytic anemia?
- Acute blood loss
- Bone marrow failure (decreased RBCs production)
- Hemolysis
- Immunologic destruction
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What is aplastic anemia?
Failure to produce ALL types of blood cells resulting in anemia, neutropenia, and thrombocytopenia.
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What anemias cause HYPOchromic (low Hgb content) or MICROcytic morphology?
- Iron deficiency anemia
- Sickle cell disease
- Thalessemia
*Lack of iron results in reduced Hgb synthesis, resulting in smaller sized RBCs.
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Ferrous sulfate has ___% elemental iron and is dosed at ____ mg TID.
20% ; 325 mg
*Iron supplementation requires 200 mg of elemental iron/day.
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What are the 4 available IV iron products?
- Iron DEXtran (InFeD & Dexferrum)
- Ferric gluconate (Ferrlecit)
- Iron sucrose (Venofer)
- Ferumoxytol (Feraheme)
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Iron needs an acidic or basic environment to be absorped?
Acidic
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How much folic acid do you receive if you are deficient?
1 mg/day x 4 months
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ESAs are contraindicated in patients with uncontrolled ______________.
Hypertension
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Epoetin alfa
Procrit, Epogen
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