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Carbamazepine
Tegretol - extensive hepatic metabolism. Inducer!! Causes SIADH, osteomalacia, folate deficiency, teratogenic, suicidal ideation
BBW: rash, aplastic anemia
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Ethosuximide
Zarontin - may cause rash, gum hypertrophy, suicidal ideation
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Felbamate
Felbatol - adjuntive therapy ONLY - may cause suicidal ideation. Benefit must outweigh risk!
BBW: Hepatotoxicity, Aplastic anemia
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Fosphenytoin
Cerebryx - Max of 150 mg PE/min! 75 mg FOS = 50 mg phenytoin.
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Gabapentin
Neurontin - 100% Renal elimination. May cause weight gain, suicdal ideation.
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Lacosamide
Vimpat - adjuntive therapy for > 17 y.o. May cause lack of coordination and diplopia, suicidal ideation
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Lamotrigine
Lamictal - may cause toxic dermal necrolysis - if given too fast, suicidal behavior
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Levitiracetam
Keppra - adjuntive therapy- suicidal behavior, sedation
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Oxcarbazepine
Trileptal - SIADH --> hyponatremia, hypersensitivity syndrome, suicidal behavior
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Phenobarbital
INDUCER! Hepatic failure, SJS, hypersensitivity syndrome, folate deficiency, imparied memory/concentration, preg cat D
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Phenytoin
- Dilantin - INDUCER of CYP2C19! indicated for ALL seizure types except absence and febrile seizures. Exhibits zero-order kinetics. May cause, thickening of subcutaneous tissues, acne, hirsuitism, gingival hyperplasia, Vit K deficiency, Hepatic failure, SJS, hypersensitivity syndrome, suicidal behavior, preg cat D. Range: 10-20 mg/L. DO NOT infuse faster than 50 mg/minute
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Pregabalin
Lyrica - may cause angioedema, suicidal ideation
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Primidone
Mysoline - hepatically metabolized to phenobarbital - may cause megaloblastic anemia and lupus like syndrome
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Rufinamide
Banzel - used as adj. treatment of Lennox - Gastaut in children 4 years and older and in adults. May cause a shortening of the QT interval, hyerpsensitivity syndrome, suicidal ideation.
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Tigabine
Gabitril - risk of suicidal ideation
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Topiramate
Topamax - may cause kidney stones, oligohidrosis (not adequately sweat), suicidal ideation.
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Valproic Acid
Depacon/Depakene - may cause weight gain, alopecia, thrombocytopenia, suicidal ideation
BBW: Hepatotoxicity, hemorrhagic pancreatitis, fetal valproate syndrome
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Vigabatrin
Sabril - indicated for infantile spasms. adj for complex partials. Risk of suicidal ideation
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Zonisamide
Zonegran - partial sz in adults. May cause kidney stones, weight loss, psychosis, oligohidrosis, metabolic acidosis. IS A SULFONAMIDE!
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What is the max infusion rate of phenytoin (IV)?
50 mg/min IV
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What is the max infusion rate of FOSphenytoin?
150 mg/min
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