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Broad Activity Spectrum
Kills a wide variety of organism
Narrow Activity spectrum
kills a specific organism
Bacteriostatic
prevents growth of an organism
Bacteriolytic
lyses bacteria
Bacteriocidal
kills the organism
Therapeutic index
ratio of toxic dose / theraputic dose
1st generation
first release of antibiotic; has G+ action
2nd generation
G+ and G- action but not psedomonas
3rd generation
G- including pseudomonas
4th generation
slightly expanded spectrum
Cell wall active antibiotics
target peptidoglycan
Beta Lactams
Prevent peptidoglycan cross linking
Penicillins
Beta Lactam that prevents peptidoglycan cross linking
Cephalosporins
Beta lactam that prevents peptidoglycan cross linking
Vancomycin
prevents peptidoglycan transglycosylation
Bacitracin
Prevents monomers of PG transport across membrane which prevents PG synthesis
Fluoroquinolones
inhibit DNA gyrase to prevent replication
Rifamycins
inhibit RNA polymerase to prevent transcription
Cell Membrane Disruptors
Not much difference between their membrane and ours so difficult to make
Polymyxins
have low theraputic index because we have a membrane too
Cubicin
collapses PMF of bacteria
Folate inhibitors
bacteria make own folic acid by PABA to make nucleotides
Sulfa drugs
structurally similar to PABA and inhibit the synthesis
Trimethoprim
inhibit folic acid synthesis
Protein Synthesis Inhibitors
work on ribosome or tRNA to block protein synthesis
Amantadine
targets uncoating step of virus; collapses the change in pH of the endocytic vessicle
Rimantadine
targets uncoating step of virus
Nucleoside Analogs
competative inhibitors of DNA polymerase or RNA polymerase
Reverse Transcriptase inhibitor
Kills retroviruses by blocking reverse transcriptase
Protease Inhibitors
inhibits the cutting up of polyprotein
Neuraminidase inhibitors
doesn't allow release of virus during budding
ergosterol
in fungal plasma membrane
polyenes
topical inhibition of ergosterol
Azoles
antifungal ergosteral inhibition
Echinocandins
target different linkage of fungal cell wall
Griseofulvin
inhibits fungal cell division; low theraputic index
Metronidazole
target flagyl in intestinal infections
Chloroquine
treats malaria; becoming resistant
Artemisinin
comes from a plant; treats malaria
Ivermectin
treats worms in tissues
Piperazine
treats intestinal worms
Minimum inhibitory concentration
minimum dilution that is effective
Kirby bauer test
uses filter paper to measure zone of killing
E-test
measures MIC and tests multiple antimicrobiols
Efflux Pump
pumps antibacterial out once it enters
F-Plasmid
can be transmitted from one cell to another through horizontal gene transfer
F' plasmid
part that leaves Hfr; f plasmid w/ bacterial gene
R plasmid
F plasmids with multiple resistance genes
Author
epaynich
ID
16451
Card Set
Lecture 29.txt
Description
Micro 221 Lecture 29
Updated
2010-04-27T19:18:36Z
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