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Lecture 27.txt
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Endotoxin
lipid a of G- LPS; binds to 2 receptors producing a strong cytokine signal which can cause septic shock
LPS binding protein
Binds LPS from lysed bacterial invaders
Septic Shock
capillaries become leaky, blood is lost, organ failure, DIC, death
Limulus Amoebocyte Assay
Detects tiny amounts of LPS by injestion into limulus blood to see if it coagulates
Exotoxins
protein which is very toxic
A-B toxin
toxin with 2 parts that interferes with cell signaling, stops protein synthesis and interferes with electrolyte balance
Anthrax toxin
A2B toxin which interferes with CAMP production and causes swelling; vaccine can be made for B part
Lethal factor
part of anthrax toxin that interferes with cell signaling which leads to death
Edema factor
part of anthrax toxin that increases camp production causing leaking of water and swelling
hemolysins
lyse cells on blood agar
phospholipase
remove phospholipid head group so you loose the cell membrane and the cell lyses
Efolitive toxin
produces by staphylococcus; dissolves the glue that holds the dermis to the epidermis so the epidermis flakes off
Hyaluranidase
destroys hyaluranic acid which connects cells; makes the cell more permeable
Super antigen toxin
cross links t cell to APC without an antigen present which activates the Tcell; causes massive T cell activation which causes septic shock
Toxic shock
fatal form of superantigen toxin which causes huge amounts of blood loss
Necrotizing Fasciitis
fatal form of superantigen toxin
induced autoimmunity
immune mimicry; rheumatic heart disease
Acute Glomerulonephitis
type III hypersensitive complex which causes damage to kidneys
Acute Rheumatic Fever
antibodies to strep M protein recognize a protein on the heart muscle; type II Hyper sensitivity
Interferon repressor
Stop cell synthesis of interferon so viruses can move to other cells
P53 inhibitor
inhibits apoptosis
MHC-1 analog
reverses NK-mediated killing of viral infected cells
Syncytium
fused groups of cells caused by virus budding so the virus avoids antibodies
keratinase
allows fungal invasion of deeper tissues by eating away at the tough layer of top skin
Author
epaynich
ID
16449
Card Set
Lecture 27.txt
Description
Micro 221 Lecture 27
Updated
2010-04-27T19:17:53Z
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