Lecture 27.txt

lipid a of G- LPS; binds to 2 receptors producing a strong cytokine signal which can cause septic shock

Binds LPS from lysed bacterial invaders

capillaries become leaky, blood is lost, organ failure, DIC, death

Detects tiny amounts of LPS by injestion into limulus blood to see if it coagulates

protein which is very toxic

toxin with 2 parts that interferes with cell signaling, stops protein synthesis and interferes with electrolyte balance

A2B toxin which interferes with CAMP production and causes swelling; vaccine can be made for B part

part of anthrax toxin that interferes with cell signaling which leads to death

part of anthrax toxin that increases camp production causing leaking of water and swelling

lyse cells on blood agar

remove phospholipid head group so you loose the cell membrane and the cell lyses

produces by staphylococcus; dissolves the glue that holds the dermis to the epidermis so the epidermis flakes off

destroys hyaluranic acid which connects cells; makes the cell more permeable

cross links t cell to APC without an antigen present which activates the Tcell; causes massive T cell activation which causes septic shock

fatal form of superantigen toxin which causes huge amounts of blood loss

fatal form of superantigen toxin

immune mimicry; rheumatic heart disease

type III hypersensitive complex which causes damage to kidneys

antibodies to strep M protein recognize a protein on the heart muscle; type II Hyper sensitivity

Stop cell synthesis of interferon so viruses can move to other cells

inhibits apoptosis

reverses NK-mediated killing of viral infected cells

fused groups of cells caused by virus budding so the virus avoids antibodies

allows fungal invasion of deeper tissues by eating away at the tough layer of top skin