Lecture 25 notecards.txt

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Allergic response mediated by IgE; immediate response

Fc part binds to mast cells causing sensitization

Coated with IgE; Fab part binds to antigen; then releases the granules(histamine, leukotriene, prostaglandin)

released by mast cell after second exposure to an allergen

cause mucus membranes to open and secrete fluid

cytokine released by mast cell

first exposure of allergen which causes Fc part of IgE to attach to mast cells

injection of allergen that causes it to bind to IgG so it can't bind to IgE; using anti IgE antibodies that doesn't allow it to bind to mast cells

cause leaking of capillaries and hypovolemia leading to death

Mucus membrane secretes fluids due to extra permeability in capillary bed

cytotoxic response to haptens; cells are killed

small molecule recognized by immune system

??

Baby is RH+ and has proteins on its RBC so mothers immune system attacks and kills the baby

Anti RH antibodies given to mothers with RH+ babies and RH- blood

immune complexes are formed; mediated by antibody and antigen agglutination

Antibody and antigen agglutination

Complexes formed are too small for immune system to recognize; get stuck in capillary membranes; NK and compliment system come in

mediated by Th Cells and macrophages

causes tissue destruction due to poison ivy, tissue rejection

Reduced by Corticosteroids

Control T cells so rejection doesn't occur

weakened immune system due to anti-rejection drugs

Own proteins are recognized as foreign

B cells recognize acetyl choline receptors so muscles can't contract

makes muscles contract

Beta cells that produced insulin are recognized by Tc cells and are destroyed

Collagen is recognized by Th cells to cause inflammation; B cells produced anti collagen antibodies --> type III hypersensitivity

Pieces of DNA are recognized by B cells; immune complexes form; type III Hypersensitivity

Antibodies mimic TSH and overstimulate thyroid causing goiter

overstimulates in graves disease

hyper active thyroid

Oral presentation of antigens stimulates production of suppressor T cells

person lacks part of the immune system

genetically inherited immunodeficiency

AIDS and measles; weakens immunity