lecture 22.txt

Antigen binding site of an antibody

Constant region of the antibody

place in antibody with variation that allows it to recognize a particular protein

not many variations in the part of the antibody

small region of antibody

The long chain of the antibody

bind to the viral capsid proteins and not allow them to bind to their receptor

clumps pathogens by binding them together so they can be easily phagocytized

attaches to pathogen as an "eat me" tag for phagocytes

Fab part of antibody binds to pathogen; fc part binds to NK cell which then kills the infected cell

First Antibody produced in response to an infection; Fc Parts bind to form pentameter; neutralizes, immobolizes, agglutinates, complement system; does NOT opsonize or ADCC

Major Circulating antibody in serum; long half life; transports across placenta; neutralies, immobolizes, agglutinates, opsonizes, complement, and ADCC; ALL 6!

forms dimer; most produced; secreted in mucous; found in breast milk; neutralizes and immobilizes

Short half life; found on memory cells and basophils in the lungs

Antbodies begin as IgM, cytokines cause a developmental change, IgG is made in serum and IgA is made in secretions

can produce IgG right away upon second exposure

genes are put together in a variety of ways to account for the millions of antibodies

variable region of the light chain

diversity region of the light chain

Joining region of light chain

Once activated Th cells binds to B cell it secretes cytokines which: 1. causes replication of B cell 2. turns some clones into plasma cells and some into memory B cells

secrete antibodies

Deletion of B cells that recognize self antigens

B cells that bind an antigen in developing bone marrow die; B cells with no Th cell becomes anergic

B cell that recognizes a self antigen but has activated Th cell and that lacks energy