Neuropath - Infection / Inflammation

Basilar Menigitis

Acid Fast Bacili in TB

Bacterial Meningitis

Bacterial Meningitis with PMNs

Abscess

Granuloma as may be seen in TB, Fungi, Spirochetes, Sarcoid, foreign bodies

Multinucleated giant cells as seen in granulomas

Cryptococcus demonstrating large, budding yeast with a zone of clearing around them

Coccidioides - small yeast in a bigger endospore surrounded by PMN's

Aspergillus - narrow, regular, acute branching

Mucormycosis - broad, irregular, branching at 90

Candida - budding yeast with pseudohyphae which is angioinvasive

Toxoplasmosis

Cystecircosis

Cystecircosis

Cowdry A Body

Single intranuclear inclusion with a large, clear zone

Seen in HSV, CMV, VZV, SSPE

Cowdry B

Small inclusions without halo outside nucleus

Seen in Polio

HSV Encephalitis

Negri Body

Seen in Rabies

Chronic plaques in the WM with clear boards sparing the GM

Gross MS in the spinal cords. There is no tract or vascular predilection