-
HTN prego
methyldopa- false NT==> alpha 2 agonist
-
cardio meds that alter sexual function
- thiazides
- spironolactone
- congeners
- prazosin
-
-
postural hypoTN with first dose
prazosin, tell pts to take first dose before bed
-
prazosin
- a1 antagonist
- dilation of resistance and capacitance vessels
-
-
labetolol
- a/b blocker
- **high antiHTN efficacy**
-
supraventricular arrhythmia tx
b blocker
-
severe aortic aneurysm tx
nitroprusside + b blocker or verapamil(Ca-c-b)
-
hydralazine
inhib of IP3 mediated Ca release from SR
-
minoxidil
open K channels in arteriolar SM
-
diazoxide
- open K channels in arteriolar SM membrane
- - can cause hyperglycemia
- - sulfa
-
Fenoldopam
D1-r agonist mainly in renal arteries==> vasodilation and inhibition of Na reabsorption
-
verapamil and diltiazem
Ca channel blockers
-
dihydropyridines
Ca-channel blockers
-
aliskiren
- competitive renin inhibitor ==> dec AI, AII and aldo and inc renin
- **no prego- teratogen**
-
-prils
- ACE inhibitors
- **no prego-teratogen**
-
-sartans
- angiotensin receptor antagonist
- **no prego- teratogen**
-
HTN med to avoid with gout
diuretics
-
HTN drugs to avoid with cardiac failure
Ca channel blockers
-
HTN meds to avoid with bradyarrhythmia
b-blockers and Ca channel blockers
-
HTN meds to avoid with advanced renal insufficiency
K sparing diuretics, ACEi and ARBs
-
drugs to avoid with bilateral renal artery stenosis
ACEi and ARBs
-
meds to avoid in bronchospastic disease
b- blockers
-
nitrate + sildenafil =
profound hypoTN ~> death
-
best anti-arrhythmic post MI
- IB- Lidocaine, mexilitene or phenytoin
- (IC are C/I==>proarrhythmic)
-
largest increase in HDL
niacin
-
only lowers LDL
bile acid binders
-
no effect on LDL, used for T3HL and hypertriglyceridemia
fibric acid derivitives (gemfibrozil)
-
postural hypotension after first dose
Prazosin: a-1 blocker
-
INH res
PM==> activator modification
-
FQ res
PM==> target ex mod
-
-
VRSA res
GA==> altered PG structure
-
MLSBs res
GA==> ribosome mod
-
beta- lactam resistance
GA==> beta- lactamase
-
ESBL res
- GA==> extended spectrum beta- lactamase prod
- prev in G- rods
-
aminoglycosides, Streptogramin A and B- lactam res
GA==> Abx mod
-
-
vancomycin res
innate in G- organisms
-
Red man syndrome- flushing and rash after infusion
vancomycin
-
INH
- inhibits mycolic acid syn
- - A/E: hepatotox, peripheral neuropathy
-
Rifampin
- DdRP inhibitor
- A/E: hepatitis, flu-like sx and orange discoloration of body fluids, purpura (STOP TX), dec levels of Est, anti-epileptics and NNRTIs
-
Pyrazinamide
- - inhibits TB growth in TB when intralysosomal
- - **short course (6 mt) MDR-TB
- - A/E: hepatitis and gout
-
Ethambutol
- inhibits aribinogalactan syn
- A/E: optic neuritis and color blindness
-
streptomycin
- - aminoglycoside Abx- extracellular organisms (TB)
- a/e: nephrotox, ototox
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