Systemic therapy (chemo, hormonal, immune) that is directed to eradicate micro-metastatic disease or to kill off residual tumor cells post surgery or radiation therapy. Frequently given with no or little evidence of disease to decrease chance of recurrence.
Systemic, pre-operative therapy designed to de-bulk of decrease tumor vascularity in addition to killing micro-metastatic spread. Also called pre-operative therapy.
The utilization of agents or procedures, both local and systemic (chemotherapy, surgery, radiation, pain management) to give temporary symptomatic relief and provide comfort.
Any therapy that may arrest the cancer, frequently involves non-traditional medicine, extremely high dose chemotherapy, investigal agents.
No clinical evidence of malignancy for 1 month after final treatment. Solid organ tumors.
Complete Response/Remission (CR)
50% reduction in measurable tumors; no new lesions, metastasis, or disease progression (NOTE: Stages I-IV for solid organ tumor only, not for blood tumors)
Partial Response (PR)
Clinical CR (CCR)
Documented by physical or radiologic exam only
Pathological CR (PCR)
Documented by biopsy and Clinical CR
Mass that does not increase (or decrease) in size by 25%
Mass that increases in size by 25%, or reappearance of a lesion after CR
No relapse or recurrence from last treatment to year 5
Time from CR until disease relapse or death
Time from treatment until time of death
BSA = SQRT( (cm*kg)/3600 )
Lowest point of normal function > 10-14 days from chemotherapy