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Systemic therapy (chemo, hormonal, immune) that is directed to eradicate micro-metastatic disease or to kill off residual tumor cells post surgery or radiation therapy. Frequently given with no or little evidence of disease to decrease chance of recurrence.
Adjuvant Therapy
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Systemic, pre-operative therapy designed to de-bulk of decrease tumor vascularity in addition to killing micro-metastatic spread. Also called pre-operative therapy.
Neoadjuvant Therapy
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The utilization of agents or procedures, both local and systemic (chemotherapy, surgery, radiation, pain management) to give temporary symptomatic relief and provide comfort.
Palliative Therapy
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Any therapy that may arrest the cancer, frequently involves non-traditional medicine, extremely high dose chemotherapy, investigal agents.
Salvage Therapy
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No clinical evidence of malignancy for 1 month after final treatment. Solid organ tumors.
Complete Response/Remission (CR)
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50% reduction in measurable tumors; no new lesions, metastasis, or disease progression (NOTE: Stages I-IV for solid organ tumor only, not for blood tumors)
Partial Response (PR)
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Clinical CR (CCR)
Documented by physical or radiologic exam only
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Pathological CR (PCR)
Documented by biopsy and Clinical CR
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Stable Disease
Mass that does not increase (or decrease) in size by 25%
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Disease Progression
Mass that increases in size by 25%, or reappearance of a lesion after CR
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Cure
No relapse or recurrence from last treatment to year 5
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Disease-Free Survival
Time from CR until disease relapse or death
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Overall Survival
Time from treatment until time of death
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BSA Formula
BSA = SQRT( (cm*kg)/3600 )
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Lowest point of normal function > 10-14 days from chemotherapy
Nadir
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Nadir values (hold chemo if below)
ANC > 1500/mm3 ... WBC > 3000/mm3 ... PL > 100,000/mm3
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