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In Mononucleosis you should find hyperplasia of what part of the lymph node and of the spleen?
Paracortex of LNs and periarterial lymphatic sheath of the white pulp of spleen.
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EBV infects these three main areas/organs:
Oropharynx, liver, B-cells
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Infectious Mononucleosis is caused by which two bugs?
EBV and sometimes CMV
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What test do you use for mononucleosis screening and then confirmation if it is due to EBV?
Monospot test--heterophile antigen pos for IgM (lyse sheep RBCs) and then EBV viral capside antibodies
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What marker is found in ALL?
TdT, a marker of pre-T and pre-B cells
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This ALL translocation is associated with a better prognosis:
t (12, 21)
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This cell surface markers are associated with B-ALL:
CD 10, 19, 20
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These cell surface markers are associated with T-ALL and seen where in teens?
CD2-8, thymic mass in teens--lymphoma
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ALL needs chemotherapy prophylaxis to which areas?
Scrotum and CSF
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This leukemia affects Down's kids older than 5:
ALL
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This leukemia affects Down's kids younger than 5:
Acute Megakaryocytosis Leukemia
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This disease is associated with Auer Rods, which are crystal aggregates of MPO
AML
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This leukemia is common in adults, gen 55+, and the M3 form responds well to all-trans retinoic acid due to it's binding to dysrupted RAR-receptors and inducing the maturation of certain cells:
AML (myeloblasts).
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Translocation associated with AML:
t (15:17)
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