Microbiology Block 2

-use broad spectrum antibiotics: Cephalosporins and azithromysin
-active immunozation with conjugated PRP vaccines
-Rifampin prophylazxis to eliminate carriage in children at risk

-minute, encapsulated gram-negative coccobacillus
-causes pertussis or whopping caugh
-life threatening in babies
-transmission: direct contact or inhalation of aerosols
-loss of ciliary mechanism leads to build up of mucus and blockage of the airways

receptors that recognize and bind to ciliated respiratory epithelial cells
-toxins that destroy and dislodge ciliated cells

culture on Bordet-Gengou agar
-contains high % of blood (20-30%) to inactivate inhibitors in the agar

Erythromycin

DTaP: acellular vaccine containing pertussis toxoid and 4 other purified proteins is recommeneded
-Given to children and tetanus toxoids

-obligate parasites of man and animal
-Major Pathogens:
    *Acute pyogenic: normally invasive infection
    * Chronic infections w/ H. Influenza as 2^o pathogen
    Responsible for: epiglotitis menigitis, otitis, Pneumonia (EMOP) (lower respiratory disease) cellulitis, arthritis, sinusitis, and conjunctivitis
Habitat and Transmission:
  Habitat: upper respiratory tract
  Tranmission: by respiratory droplets

-polysaccharide capsule: capsular type b most invasive
-IgA protease
-most cases of meningitis in children younger than 2YOA
b/c maternal antibody has died off and child immune response can be inadequate
-NO exotoxins

Microscopy: sensitive test for H. Influenza in CSF, Capsular antigen present in serum or cerebrospinal fluid
Culture: chocolate agar (growth requires both factors X (hematin) and V (NAD)
Memory Tool: when a child has "flu" mom goes to five (V) and dime (X) store to buy some chocolate