Anti-Emetics

Anti-Emetic

- Description: Metoclopramide is a Dopamine antagonist similar to procainamide, but with few anti-dysrhythmic or anesthetic properties. Its anti-emetic properties stem from gastric emptying and desensitization of the vomiting reflex.

- Indications: Nausea and vomiting

- Contraindications: Hypersensitivity, seizure disorders, GI obstruction or perforation, and breast cancer.

- Precautions: CHF, hypokalemia, renal impairment, GI hemorrhage, intermittant porphyria.

• - Dosage/Route: 10 - 20 mg IM; 10 mg slow IV (over 2-4 minutes)
• Pedi: 1-2 mg/kg/dose

Anti-Emetic

- Description: Promethazine is an anticholinergic agent that enhances the effects of analgesics and potent anti-emetic.

- Indications: Nausea and Vomitting, motion sickness, enhance effects of analgesics, and to induce sedation.

- Contraindications: None

- Precautions: Hepatic, respiratory, or cardiac impairment, asthma, hypertension, elderly, debilitated patients.

• - Dosage/Route: 12.5-25 mg IV/IM/PR
• Pedi: 0.5 mg/kg IV/IM/PR

Antiemetic

- Description: Prochlorperazine is a phenothiazine derivative similar to chlorpromazine with potent antiemetic properties and fewer sedative, hypotensive, and anticholinergic effects.

- Indications: Severe nausea and vomiting or acute psychosis.

• - Contraindications: Hypersensitivity to
• phenothiazines coma or depression.

- Precautions: Breast cancer, children with acute illness or dehydration.

• - Dosage/Route: 5 to 10 mg IV/IM.
• Ped: 0.13 mg/kg IV/IM/PR if > 10 kg or > 2 years.

Anti-Emetic

- Description: selective blocking agent of seratonin 5-HT₃ receptor type

- Indications: Prevention of nausea and intractible vomiting.

- Contraindications: None

- Precautions: may mask a progressive ileus and/or gastric distension.

- Dosage/Route: 4 mg IV or PO