If the liver and spleen are not affected by acute leukemia what anemia will be present?
normocytic, normochromic
what cells will be present and usually predominante in an acute leukemia patients differential?
Blasts
This is used to attain better discrimination in therapy and prognosis
FAB classification
FAB classification is based on what four things?
WBC morphology
Cytochemical staining
immunologic marker studies
cytogenetics
what type of blast has prominent nucleoli and and auer rods present in 50-60%.
AML blasts
what type of blast has indistinct nucleoli and never has auer rods.
ALL Blasts
These are stains used to aid in the diagnosis and classification of leukemia.
cytochemical staining
Cytochemical staining uses the presence or absence of ________ or ________ to differentiate hematopoietic cells.
enzymes
lipids
This leukemia resembles M1 except smear shows maturation to or beyond promyelocytes.
M2-AML
What is the most common type of AML
M1 and M2
True or False
auer rods are often present in M2
true
in this leukemia cells are all promyelocytes
M3-APL
what type of leukemia has cells that have a kidney shaped or biloben nucleus, moderate cytoplasm, heavy primary granulation, and auer rods are common and in multiple
M3-APL
what type of leukemia has a high incidence of DIC.
M3-APL
in M4 leukemic cells are called _______.
myelomonocytic cells
what type of leukemia is is characterized by both monocytic and granulocytic differentiation.
M4-AMML
what type of leukemia has a large heterogenous lymphoblast morphology.
L2-ALL
what is the four characteristics of nucleus lymphoblast morphology in L2-ALL.
irregular in shape
clefting and indentation
heterogenous chromatin pattern
one or more nucleoli
what are the two characteristics of a laymphoblast's cytoplasm.
variable, often moderately abundant
variable cytoplasmic vacuolization
what is B cell ALL aso called?
burkitt's leukemia or lymphoma
this leukemia accounts for 2-5% of all ALL cases and has asymmetrical enlargement of lymph nodes.
B-cell Leukemia
what are the two other names that Chronic Myelogenous Leukemia is known as?
Chronic Myeloid Leukemia
Chronic Myelocytic Leukemia
This is the most common type of leukemia in adults.
CLL
what are the five symptoms of CML?
Weight loss
enlarged spleen
fever
night sweats
malaise
This is a diverse group of diseases characterized by proliferation of a single clone of cells producing a monoclonal immunoglbulin or immunoglobulin fragments.
Plasma Cell Disorders
What are the three causes of multiple myeloma?
Radiation
Chemical agents (agricultural)
certain medical conditions
True or false
Multiple myeloma is not normally a myloproliferative disorder
True
this disorder causes bone pain in 2/3 of cases, anemia, fatigue, SOB, constipation, and abdominal pain.
Multiple myeloma
This disorder involves IgG or IgA, and causes marked rouleaux, elvated ESR, Presence of flame cells in BM
Multiple myeloma
This disorder is characterized by a predominance of prolymphocytes in bone marrow and marked rouleaux
waldenstrom's macroglobulinemia
this dye is used to differentiate AML or AMoL from ALL. Positve for AML and AMoL (blue-black precipitate). Negative for ALL (No precipitate)
MPS
This stain is soluble in lipids and penetrates granules in granulocytes and monocytes. granules stain black.
SBB
Sodium fluoride inhibits this dye's activity in monocytes and macrophages but not other cells.