Lecture 9

Muscle Movement in PNS (somatic)
- - somatic (voluntary)
- * affects skeletal muscles
- * AcH works at neuromuscular junction:
- - AcH released
- - Binds to receptors on muscle fibers
- - open sodium channels in membranes of muscle cell
- - stimulates muscle contraction
Muscle Movement in PNS (autonomic)
- - Autonomic (involuntary)
- * AcH is also important in parasympathetic system
- * blocking AcH prevent messages
Curare
- - mixture of toxic plants used by South American tribes to produce dart poison
- - When injected, causes muscle paralysis
- - Strength gauged on effect:
- * One-tree curare
- * three-tree curare
- - Mixtures vary by region & tribe
- - can contain up to 30 spp.
- Chondrodendron tomentosum (Menispermaceae)
- Curarea toxifera(Menispermaceae)
- Strychnos toxifera (Loganiaceae)
- - Species used in curare
- - 8 spp. native to Peru & Brazil
- - stem & root bark
tubocurarine
- - active ingredeint in curare
- - Muscle relaxant during surgery
- -Blocks AcH at neuromuscular junction in somatic NS

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patelkb

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Lecture 9

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lecture notes

Updated

2010-04-22T00:14:37Z

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