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I
The transportation, care, and use of animals should be in accordance with the AWA and other applicable Federal guidelines and policies
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II
Procedures invovling animals should be designed and performed with due consideration of their relevance to human and animal health, the advancement of knowledge, or the good of society
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III
The animals selected for a procedure should be of an apporpiate species and quality and the minimum number required to obtain valid results. Mthods such as mathematical models, computer simulations, or in vitro biological systems should be considered
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IV
Proper use of animals, including the avoidance or minimization of discomfort, distress, and pain when consisten with sound scientific practices, is imperative. Unless the contrary is established, investigators should consider that procedures that cause pain or distress in humanss may cause pain and distress in animals
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V
Procedures with animals that may cause more than momentary or slight pain or distress should be performed with apporpriate sedation analgesia, or anesthesia.
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VI
Animals that would otherwise suffer severe or chronic pain or distress that cannot be relieved should be painlessly killed at the end of the procedure or, if appropriate, during the procedure.
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VII
The living conditions of animals should be appropriate for their species and contribute to their health and comfort. Normally, the housing, feeding, and care of all animals used for biomedical pruposes must be directed by a veterinarian or other scientist trained and experienced in the proper care, handling, and use of the species being maintained or studied. In any case, veterinary care shall be provided as indicated.
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VIII
Investigators and other personnel shall be apporpriately qualified and experienced for conducting procedures on living animals. Adequate arrangements shall be made for their in-service training, including the proper and humane care and use of laboratory animals.
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IX.
Where exceptions are required in relation to the provisions of these Principles, the decisions should NOT rest with the investigators directly concerned but should be made, with due regard to Principle II, by an appropriate review group such as an IACUC. Such exceptions should not be made solely for the purposes of teaching or demonstration.
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