-
S/S dehydration
- Bun:Scr
- weakness, dec urine, tachycardia
-
thiazide MOA
- inhibib Na Cl pump on proximal loop
- -protective of ca
- -weaker than k sparring
-
loop MOA
- inhib Na K pump on ascending loop
- -less Na reabsorbed, also less ca over time - osteoprosis
-
inc in aldosterone -->
inc Na and H20 renention
-
sprinolactione MOA
decreases aldosterone, dec- NA and water retention
-
-
metoclopramide in the elderly
dopamine blocker
-
tx of protenuria
- ace-- efferent arterioloar dilation
- control BP, glucose
-
CKD- anemia
iron, folate, b12
-
CKD- bone
- inc in phos: use phosphate binders
- dec vit D: compensation for phos: suppement
- inc K: monitor
-
phosphate binders
- 1. aluminum: Al tox - altenosa, emphage
- 2. calcium: hypercalceimia, Phoslo, Tums
- 3. neither: forselo, renegel
-
-
metabolic acidosis tx
sodium bicarb, b agonist, ben albuterol, kayexolate
-
s/s liver dysfunction
NV loss app, dia, malaise, ab pain, jaundice
-
-
-
-
-
interferon 2 alpha
- PEG- pegasys, peg iner- extends to weekly administration
- BBW: autoimmune dx, psychiatrics, depression, suicide
- se: flu-like, neutropenia, thrombo, pneumitis, pancreatitis, myalgia, arrhythmia, inc LFT,
-
NRTI for hep b SE
- BBW: lactic acidosis, helpatomegali
- ha, fatigue, nv, diarr, inc LFT,
-
NRTI for hep b names
- lamivudine- epivir
- adefovir- hepersa (CI renal)
- tenofovir (viread)- fanconi, renal, bone
- entiecavir (barcalude)
- telbuvdine (tyzeka)- myopathy
-
hep C tx
ribavarin + interferon + PI
-
ribavarin
- MOA: inhibits replication
- ci: crcl<50
- BBW: preggers
- SE: hemolytic anemia, cv dx
- di: inc NRTI
-
PI for hep c
- boceperevir (victrelis)
- se: fatigue, anemia, neutropenia, - NEVER MONOTHERAPY
- telapravir (incevek)
- se: rash
no preggers
-
-
-
-
-
hypo causes
- hashmoto
- lithium, amiodarone, interferon
-
treatments for hypo
- levothyroxine - t4
- thyroid USP- armout thyroid- t3and t4
- liothyronine- t3- cytomel- shorter t1/2
- liotrix- t3 and t4
-
levothyroxine
- BBW: euthyroid pts
- se: inc HR, palpitaions, sweating, wt loss, arrthymias
- CI- MI, adrenal insuff
- M: w 6-8weks
-
hyper causes
- graves
- idodinem amiodarone, interferon
-
hyper tx
- radioactive iodine
- PTU
- Methmiazole
- iodines
-
thionamides MOA
inhibit synthesis of thyroid hormones by blocking oxidation of idonide in gland
-
PTU - propylthiouracil
methimazole
- PTU also blocks t4 to t3
- BBW: liver
- SE: gi upset, hepatitis, agranulocytosis
TAKE WITH FOOD
-
THYROID STORM
- caused by stress
- s/s: fever of 103, tachycardia, sweating, agitiation
- tx: PTU 900-1200 divied q 4h + SSKI q 8h + propranolol q 6h + dex q 6 h
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