diabeters

pumps insulin out of pancreas

• Glyburide (diabeta, micronase)- active
• metabolites that are renally cleared- ↑ risk of hypoglycemia in renal insuff

• Glipizide
• (glucotrol)

• Glimepiride
• (amaryl)

• SE: HYPOGLYCEMIA,
• rash, weight gain (any drug that promotes insulin promote wt gain)

• Inhibits glucose
• release from the liver, enhances muscle peripheral glucose intake

• SE: GI (transient
• diarrhea- must titrate), to a goal of 1500mg/day,

• Crcl- 1.4/1.5- you
• hold onto more drug→ lactic acidosis- IT IS NOT NEPHROTOXIC

• Advantages: wt
• loss/wt neutral, improve cholesterol levels

⇓ absorption of sugars in brush boarder of intestine

• Used at meal time
• Decreasing postprandial glucose levels

SE: flatulence, abdominal bloating

• MOA: ↓ insulin
• resistance at the PPAR gamma receptor by improving uptake and muscles

Rosiglitazones (avandia) - do not use in heart failure

Pioglitaone (actos)

SE: wt gain (edema), ↑ LDL, monitor liver associated enzymes

Repaglinide (prandin)

Nateglinide (starlix)

Basically short acting SU, increase insulin output from pancreas-- do not take if you don’teat--

take 15-30 mins before meals

stimulate insulin secretion from beta cells

MOA: decrease glucose by decreasing glucagon

Liraglutide (victoza)- 1.2-1.8mg/day

• Exanatide (byetta) 5-10mcg 2 x daily
• SE: pancreatitis, nauses (titrate)

take 60 mins within meal

prevents breakdown of GLP

• Saxigliptin
• (onglyza) 2.5-5mg daily

• Sitaglyptin
• (januvia) 100mg daily

se: nasopharyngitis, upper resp tract, peripheral edema, rash,

take immediately before a meal

• lispro, aspart, glulisine
• humulog, novolog, apidra

with meals

• humulin r
• novolin r

take 30 mins before meal

• humulin N .. L
• Novolin N... L

BID

• determir (levemir)
• gargine (lantus)