MOA

• Inhibits conversion of AT1 to AT2 which is a potent vasoconstrictor
• Inhibits bradykinin breakdown
• Increasesnplasma renin activity due to a decrease in AT2 and therefore results in decreased aldosterone and therefore a decrease in sodium and water retention

Increased urinary excretion of sodium and water by inhibiting sodium reabsorption in the early distal tubles

Decreases plasma and extra cellular volume therefore decreases cardiac output and peripheral resistance

• Inhibits Xanthine Oxidase and therefore inhibits Uris acid synthesis
• The metabolite oxypurinol also inhibits xanthine oxidase

Inhibits neutrophil migration, adhesion and Phagocytosis to the inflamed area. Has no effects on the production of Uric acid or the excretion

Selectively inhibit the presynaptic reuptake of serotonin

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• Anti-inflammatory, immunosuppressive and antimitotic activity against cutaneous fibroblasts and epidermal cells. They are also vasoconstrictive.

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inhibits calcineurin thus blocking t cell proliferation And preventing release of inflammatory cytokines

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• Irreversibly inactivate the hydrogen/potassium ATPase enzyme system (proton pump), suppressing both stimulated and basal acid secretion. When PPIs are stopped, acid secretion is restored by synthesis of new hydrogen/potassium ATPase.

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