How would a patient with pyelonephritis present?
Fevers, chills, flank pain, CVA tenderness, hematuria and WBC casts.
UTI bug that is the 3rd leading cause of UTI -> Large mucoid capsule and viscous colonies.
ToRCH infection that causes:
Patent ductus arteriosus
+/- blueberry muffin rash
How would the mother present?
- Transmitted via respiratory droplets
Mother: Rash, lymphadenopathy, and arthrtitis
What organism will cause vesicular rash on palms and soles and ulcers in oral mucosa in children?
Coxsackievirus type A
What organism causes a cough, coryza, conjunctivitis, and blue-white (koplik) spots on buccal mucosa followed by a rash that starts form the head and goes down in children?
Measles virus (rubeola) a paramyxovirus = Enveloped ss(-)linear virus.
Sexually transmitted disease associated with painful genital ulcer and inguinal adenopathy?
This is a chancroid caused by Haemophilus ducreyi
What could cause the following findings in a HIV-positive patient: pleuritic pain, hemoptysis, and infiltrates on imaging.
This is invasive aspergillosis caused by Aspergillus fumigatus
What causes fever with dysphagia, drooling, and difficulty breathing due to edematous "cherry red" epiglottis in an nonimmunizaed child?
This is epiglottitis caused by H. influenzae type B.
What antibacterial disrupts the bacterial cell membrane? What does it treat? What are its toxicities?
- Resistant gram-negative infections.
TOXICITY: neurotoxicity and acute renal tubular necrosis.
What antibiotic blocks mRNA synthesis? What does it treat? What are its toxicities?
Minor hepatoxicity, increases P450, orange body fluids.
- Mycobacterium tuberculosis, leprosy, meningococcal prophylaxis and chemoprophylaxis in contact of children with H. influenzae type B.
What is the treatment for Hodgkin's Lymphoma and what is the mechanism of action of each?
Adrianmycin= doxorubucin - stabilizes topoisomerase II complex
Bleomycin - free radical creation on DNA
Vinblastine- inhibits microtubule formation
Dacarbazine- alkylating agent of DNA
What is the mechanism of action of cyclosporine?
Used in transplant and autoimmune disorders.
Inhibits production and release of IL-2 -> no induction of cytotoxic T cells
What is imatinibs MOA in chronic myeloid leukemia?
tyrosine kinase inhibitor of brl-abl -> promotion of apoptosis.
What is the most likely glucose associated disease that presents with severe fasting hypoglycemia, increased glycogen in the liver, hepatomegaly, and increased blood lactate?
THis is a deficiency in Glucose-6-phosphatase which inhibits G-6-P to glucose. This is VOn Gierke's disease.
What bone disease is most associated with hyperparathyroidism?
osteitis fibrosa cystica
What are the side effects for the drug that is used to treat an unstable AIDS patient with cryptococcus neoformans pneumonia?
- Treatment = amphotericin B
- S/E= fever, chills, hypotension, nephrotoxicity, and arrhythmias(due to prolonged QT intervals)
What drugs produce the following side effect when mixed with alcohol:
flushing, tachycardia, headaches, and vomiting?
- This is a disulfiram-like reaction:
How do you diagnose Zollinger-Ellison syndrome?
With the secretin test. Secretin would inhibit antral gastrin but in ZE it will cause an increase in gastrin.
What tumors are associated with polycythemia?
- Hepatocellular carcinoma
- Renal cell carcinoma
- Uterine myomata
What is the most common antibiotic to treat traveler's diarrhea in adults?
What is the spectrum of Ampicillin and Amoxicillin? What are the side effects?
- gram positive bacteria and
- Haemophilus influenzae
- E. coli
- Listeria Monocytogenes
- Proteus mirabilis
S/E: ampicillin rash and pseudomembranous colitis
What are the 2nd generation cephalosporins and what is their bacterial spectrum?
- Cefoxitin, cefaclor, cefuroxime
- gram-positive cocci
- Haemophilus influenza
- Enterbacter aerogenes
- Proteus mirabilis
- E. coli
- Klebsiella pneumoniae
What is the only bactericidal protein synthesis inhibitor antibiotic? What are they good against and how is resistance built?
Aminoglycosides (Gentamicin, Neomycin, Amikacin, Tobramycin, Streptomycin)
USE: Severe gram negative rod infections
RESISTANCE: transferase enzymes that inactivate the drug by acetylation, phosphorylation, or adenylation.
What is the bacterial spectrum of the tetracyclines?
- Vibrio cholera
- Acne (propiobacterium)
- Mycoplasma pneumoniae
- H. Pylori
- Borrelia burgdorferi
Vacuum th br
Which tetracycline can be used in patients with renal failure?
What is the spectrum of the antibiotic that causes grey baby syndrome?
- Spectrum = meningitis:
- H. Influenza
- N. meningtidis
- S. pneumoniae
What drug is used to treat atypical pneumonias?
- (mycoplasma, chlamydia, legionella)
What is the bacterial spectrum for the drug that inhibits dihydropteroate synthetase?
- Gram (+), gram (-) Nocardia and chlamydia
What is the bacterial spectrum for the antibiotic that forms free radical toxic metabolites in the bacterial cell damaging DNA?
- Gardnerella vaginalis
- Anaerobes (bacteroides, cloustridium)
- H. Pylori
GET GAP on the Metro
What is the treatment for Mycobacterial tuberculosis?
Rifampin, Isoniazid(prophylaxis), Pyrazinamide, Ethambutol.
What antibiotic is known for causing tendonitis and tendon rupture?
Which brain tumor presents with pseudopalisading tumor cells and microvascular proliferation?
Which brain tumor ppresents with rod-shaped blepharoblasts?
What is the disease:
Asthma, allergic rhinitis, elevated eosinophil counts, mononeuritis multiplex, uveitis, conductive hearing loss, and muscle/joint pain
Churg Strauss syndrome (ANCA vasculitis)
What drug inhibits DNA polymerase and is ued in the treatment of acute myelogenous leukemia?
What is bacitracin sensitive and causes impetigo.
Strepococcus pyrogenes (A beta-hemolytic group A strep)