-
IL-8
- neutrophil chemoattractant
-
TNF-alpha
- - induce macrophage production of proinflammatory molecules IL-1 and PG-E2
- - activate NK cells
- - chemotaxis
-
IL-2
- induce proliferation of lymphocytes and NK cells
-
INF- alpha, beta and gamma
- - inhibit viral replication
- - activate NK cells
-
type 1 PRR
- - initiate lectin p/w of complement
- - induced by IL-6 acting on liver
- - includes mannin binding lectin and binds microbial CHOs
- - secreted molecules produced in liver that circulate in blood and lymph
- - released in an acute phase response
-
type 2 PRR
- - phagocytosis and delivery to lysosomes and MHC presentation
- - high affinity for CHO with many mannose
- -
-
type 3 PRR
- - TLR's
- - activation of NF-kB signalling p/w (a TF)
- - cytokine gene expression (prod and release)
- - macrophages, dendritic cells and epithelial cells
-
TLR's and what they bind
- - TLR-2===> peptidoglycan of G+
- - TLR-3===> dsRNA
- - TLR-4===> LPS of G-
- - TLR-5===> flagellin
- - TLR-7===> ssRNA
- - TLR-9===> unmethylated CpG DNA (bacteria and virus)
-
C1 INH
- - C1 esterase inhibitor
- - inactivates C1r and C1s
- - classical p/w regulation
-
Factor I
- - inactivates C4b in classical p/w
- - inactivates C3b in alternative p/w
-
C4b2b
- - C3 convertase of classical and lectin p/w
- - activation unit
- - requires Mg
-
C4b2b3b
- C5 convertase of classical and lectin p/w
-
C1q,r,s
- recognition unit of classical p/w
-
Properdin
- - promoter of alternative p/w
- - stabalizes C3bBb
-
Factor H
- decays C3bBb of alternative p/w
-
C3bBb
- - C3 convertase of alternative p/w
- - activation unit
-
C3bBbC3b
- C5 convertase of alternative p/w
-
CD59
- - MAC inhibitor
- - "homologous restriction factor"
- - protects host cells from complement
-
CR1
- - found on RBC, B cells, granulocytes and monocytes and m0
- - RBC transport of immune complexes
- - promotes C3b and C4b decay
- - stimulates phagocytosis
- - very common
-
CR2
- - part of B cell co-receptor
- - CD21
-
CR3
- - monocytes, m0 and granuloctes
- - stimulates phagocytosis
-
C5a>C3a
- - act as anaphylaxatoxins (C4a also_
- - they also promotes chemotaxis of n0 and monocytes
- - enhance adherance of phagocytes to vascular epithelium
-
tetrazolium dye test
- tests funcionality of n0
-
Recurring infection types seen in primary immunodeficiencies
- B cell/Ig= bacterial pneumonia
- Complement= pyogenic infection, disseminated Neisseria
- Phagocytes= uncommon systemic bacterial infections and abscesses
- Tcells= opportunistic infections (fungi, viruses, protozoa)
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