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Spore forming, Gas Gangrene/ Myonecrosis (mediated by alpha toxin), foul-sweet odor to skin discharge, renal failure, hypotension, shock
Clostridium perfringens
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Endospores, Alpha toxin (PLC, hepatic toxicity, lyses RBCs, WBCs, endothelial cells, myocardial dysfxn), encapsulation
Clostridium perfringens
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Endospores, Alpha toxin (PLC, hepatic toxicity, lyses RBCs, WBCs, endothelial cells, myocardial dysfxn), encapsulation. what's the O2 requirement?
Anaerobic
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Spore forming, Gas Gangrene/ Myonecrosis (mediated by alpha toxin), foul-sweet odor to skin discharge, renal failure, hypotension, shock. What's the shape and where are they found?
Rods. soil, H2O, sewage microbial flora in GI
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Tetanospasmin retrograde transport to CNS, generalized (most common) & localized tetanus, spore forming
Clostridium tetani
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Tetanospasmin: plasmid-encoded, heat-labile neurotoxin (A-B toxin), motility
Clostridium tetani
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Anaerobic, non-polar flagella, bacillus bacteria prone to O2 toxicity. Patient experiences jawlock spasm.
Clostridium tetani
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foodborne or transmitted via traumatic implant. Has toxin as virulence factor, anaerobic, non-polar flagella, bacillus. Causes flaccid paralysis
Clostridium botulinum.
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Antibiotic resistance, enterotoxin A (Damages mucosa leading to fluid increase & granulocyte attractant), cytotoxin B (damages mucosa). Gains foothold when normal gut bacterial flora is disrupted.
Clostridium difficile
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