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type III secretion system (introduces exoenzymes S&T), endotoxin, Alginate capsule, pilli (adherence), Exotoxin A (disrupts protein synthesis), pyocyanin, LasA & LasB (degrade elastin), antibiotic resistance (beta lactamase),
Pseudomonas aeruginosa
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slime layer, Pigments: pyocyanin (blue green- catalyzes production of superoxide and hydrogen peroxide & stimulates IL-8 release, leading to enhanced attraction of neutrophils) and fluorescein, transient in GI, corneal ulcers, hot tub folliculitis, pulmonary infections, UTIs,exotoxin A causes burn wound infections, Ecthyma gangrenosum
Pseudomonas aeruginosa
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From Water, raw veggies, flowers and easily acquired in hospital setting
Pseudomonas aeruginosa
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Rod pairs in shape, polar flagellum, aerobic, catalase +, oxidase +
Pseudomonas aeruginosa
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Polysaccharide capsule, pili, cell wall (LPS), IgA proteases, facultative anaerobic
Haemophilus influenzae
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Cell wall componts impair ciliary fxn of resp tract, common cause of disease in unvaccinated children (meningitis, epiglottitis, cellulitis), grows in same media w/ Staph aureus
Haemophilus influenzae
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Facultative anaerobic, catalase +, oxidase +, non-motile, round rods
Haemophilus influenzae
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Facultative anaerobic, catalase +, oxidase +, non-motile, round rods bacteria. Where does it reside?
Respiratory tract
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Tender, erythrematous papule on genital, chancroid (soft painful sore)
Haemophilus ducreyi
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Polymyxin (antibiotic that binds LPS) resistance
Haemophilus ducreyi
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Facultative anaerobic, catalase -, oxidase +, round rods. Where do they reside?
Human genital
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exotoxin (A&B subunits) inhibits negative regulator of adenylate cyclase --> ↑ cAMP, children younger than 1 at greater risk, whooping cough
Bordetella pertussis
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Strictly aerobic, round rods, catalase +, oxidase +, non-motile, transmitted via respiratory droplets
Bordetella pertussis
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Pertactin and filamentous hemagglutinin (binding), Adenylate cyclase/hemolysin (↑ cAMP, ↑ edema), tracheal cytotoxin, toxin that aids in attachmt & ↑ mucus secretion)
Bordetella pertussis
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Diplococci that causes Urethral/vaginal discharge, dysuria, endocervicitis, pelvic inflam disease, ophthalmia in infants
Neisseria gonorrhoeae
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Pilli, IgA protease, porin proteins, Opa proteins (outer membrane for binding/signaling), LOS (lipid A that lacks O antigen), beta-lactamase produces penicillin resistance diplococci
Neisseria gonorrhoeae
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Non-motile aerobic diplococci present in human genital tract
Neisseria gonorrhoeae
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Photophobia, petechial, purpuric, & rash, septicemia, thrombosis, Waterhouse-Friderichsen syndrome- over whelming disseminated intravascular coagulation, w/ bleeding into brain & adrenal gland
Neisseria meningitidis
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catalase +, oxidase + non-motile diplococci bacteria in human nasopharynx
Neisseria meningitidis
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Polysaccharide capsule, pilli, IgA protease, porin proteins, LOS (lipid A that lacks O antigen), transmitted via respiratory droplets and blood stream, diplococci
Neisseria meningitidis
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Zoonotic, Ulceroglandular tularemia; localized lymphadenopathy, Oculoglandular tularemia, Pneumonic tularemia
Francisella tularensis
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Polysaccharide capsule, Inhibits phagosome-lysosome fusion, beta lactamase, transmitted via tick bite, air, ingestion, and trauma
Francisella tularensis
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Spore forming,Q fever; small cell variants: extremely resistant to environmental stress and large cell variants: multiply in host monocytes or macrophages, Extremely stable in harsh environmental conditions, can survive in soil/milk for months- years, Vasculitis in skin, subcutane tissues, CNS, lungs, heart, kidneys, liver, spleen;
Coxiella burnetii
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Transmitted via inhalation of aerosols of urine, feces, amniotic fluid, or placental tissue
Coxiella burnetii
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Antigenic variation in expression of the cell wall LPS antigen, found in domestic livestock especially in pregnant animals
Coxiella burnetii
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Strictly aerobic non-motile rod bacteria that you get from Cattle, goats, pigs (with bacteria from pigs getting most severe symptoms)
Brucella
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Inhibiting phagolysosome fusion, Suppressing production of TNF-α, Preventing release of toxic enzymes from intracellular granules, induce granuloma formation. Transmitted via Contact w/ animals, unpasturized dairy
Brucella
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Zoonotic, non-encapsulated, nonfermenter, splenomegaly, intensity of fever and symptoms recur and recede at about 10 day intervals (aerobic rod bacteria)
Brucella
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Extremely sensitive to O2, endarteritis lesions, Nontender chancre, mucocutaneous rash; condylomata lata (Raised lesions, wartlike, highly infectious), Granulomatous lesions, congenital form in infants (deafness, teeth/bone malformation)
Treponema pallidum
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Thin helical bacteria, sexually transmitted, Resist phagocytosis, adhere to host fibronectin, hyaluronidase facilitates perivascular infiltration
Treponema pallidum
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Anaerobic, non-polar flagella, thin helical bacteria in human genital tract
Treponema pallidum
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No cell wall, urease +, opportunistic, Nongonococcl urethritis
Ureaplasma urealyticum
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#1 tick borne disease in US, erythema migrans (bulls-eye lesions), facial nerve palsy, zoonotic, linked to non-Hodgkin lymphomas
Borrelia burgdorferi
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Present in White-footed mice, white-tailed deer
Borellia burgdorferi
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Virulence factors mainly unknown but bacteria is Motility,and can survive in absence of iron
Borrelia burgdorferi
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Microaerobic, non-polar flagella, helical bacteria
Borrelia burgdorferi
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Slime layer, Rocky mountain spotted fever (rash, myalgia, fever, vomit, confusion), typhus, GI, periorbital swelling, stiff neck
Rickettsia rickettsii
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Giemsa stain, Specific fluorescein-labeled Abs, PCR, non-motile small bacillus aerobic bacteria
Rickettsia rickettsii
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Transmitted via hard shelled ticks, aerobic bacteria, only found in cytoplasm of eukaryotic cells of small wild animals
Rickettsia rickettsii
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P1 adhesin (adheres & inhibits ciliary action), superantigen (elicits production of TNF-α, IL1, IL6), very small bacteria shape unknown
Mycoplasma pneumoniae
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PCR, Mulberry-shaped colonies on media containing sterols, ELISA & Immunofluorescence assays. Present in human respiratory tract
Mycoplasma pneumoniae
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PCR, Mulberry-shaped colonies on media containing sterols, ELISA & Immunofluorescence assays. Present in human respiratory tract. What's the O2 requirement?
Strictly aerobic
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No cell wall, urease +, opportunistic, Nongonococcl urethritis, Adherence proteins, inhibits host catalase, activate macrophages and cytokine production. What's the O2 requirement?
Facultative anaerobic
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swineherd’s disease; swamp or mud fever), headache, myalgia, chills, ab pain, & conjunctivitis, Severe disease can progress to vascular collapse,
thrombocytopenia, hemorrhage, & hepatic/renal dysfunction
Leptospira interrogans
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what's the O2 requirement for Leptospira interrogans
obligate aerobic
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Thin helical bacteria w/ hooks, found in rodents and other small animals
Leptospira interrogans
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