cardiac drugs

  1. Hydroxymethylglutaryl-coenzyme A reductase inhibitors
    • Atorvastatin (Lipitor)
    • Crestor
    • zocor
  2. Hydroxymethylglutaryl-coenzyme A reductase inhibitors(STATINS) MOA
    decrease liver cholesterol production
  3. Hydroxymethylglutaryl-coenzyme A reductase inhibitors(STATINS) use
  4. Hydroxymethylglutaryl-coenzyme A reductase inhibitors(STATINS) contras
    allergy, pregnancy, liver disease, high liver enzymes
  5. Hydroxymethylglutaryl-coenzyme A reductase inhibitors(STATINS) SE
    • mild GI, rash, HA, high liver enzymes, myopathy
    • (report right away rhabdomyolysis)
  6. Hydroxymethylglutaryl-coenzyme A reductase inhibitors(STATINS) Labs
    • liver
    • renal
  7. Hydroxymethylglutaryl-coenzyme A reductase inhibitors(STATINS) imps
    • Check alcohol use
    • Check myopathies before and after
    • Teach to fast 12-14 hr before lipid panel
    • No abrupt d/c
    • Check eye problems
  8. Rhabdomyloysis
    Breakdown of muscle protein accompanied by myogloburia, severe renal strain, acute renal failure, death
  9. Rhabdomyloysis s/s
  10. Rhabdomyloysis
    soreness, change in urine, fever, malaise, N/V
  11. Rhabdomyloysis risks
    • Older than 65yo
    • Hypothryroidism
    • Renal insuffiecency
    • Use of cyclosporine, niacin, or erythromycin with
    • statin use
  12. Cholestryamine (questran)
    • Class: Bile acid sequestrants
    • MOA: bind bile, preventing reabsorption of bile acids from small intestines
    • (bile salts are necessary for absorption of cholelestrol)
  13. Cholestryamine (questran) uses
  14. Cholestryamine (questran) contras
    allergy, bililary/bowel obstruction, PKU
  15. Cholestryamine (questran) SE
    constipation, heartburn, nausea, belching, bloating, orthostatic hypotension, tinnitus
  16. Cholestryamine (questran) Labs
    liver, electrolytes
  17. Cholestryamine (questran) imps
    • Increase fiber and fluids
    • Take all other drugs at least 1
    • hour prior or 4-6 hr after
    • Supplement of fat vitamins (ADEK)
    • Mix powder with crushed fruit or 4-6 oz of fluid
    • Dissolve completely
    • Take just before or with meals
    • Change position slowly
    • Contact immediately if black tarry stool occurs
  18. Furosemide (Lasix)
    • Class: loop diuretic
    • MOA: block chloride and sodium reabsorption in ascending limb of the loop of henle; also activates prostaglandins, dilating blood vessels, decreases BP, PVR, SVR, CVP
  19. Furosemide (Lasix) uses
    • great for rapid dieresis; edema and pulmonary edema r/t HF,
    • liver/renal disease, control HTN, increase Ca excretion, ascites
  20. Furosemide (Lasix) contras
    allergy, hepatic coma, severe electrolyte loss
  21. Furosemide (Lasix) SE
    • hypokalemia, erythema, exfoliative dermatitis,
    • phosensitivity, dizzy, HA, tinnitus, blurred vision, hyperglycemia
  22. Furosemide (Lasix) interactions
    • increase ototoxicity: vanco, chloroquine
    • hypokalemia/increase dig toxic: digoxin and corticosteroids
    • increase lithium: lithium
    • decreased effects: NSAIDS
    • hyperglycemia: sulfonylureas
  23. Furosemide (Lasix) imps
    • k supplement needed
    • eat k rich foods (bananas,
    • oranges, apricots, dates, raisins, broccoli, potatoes, wheat bread, legumes)
  24. s/s of hypokalemia
    • weakness, leg cramps, and other cramping of
    • muscles
Card Set
cardiac drugs