-
Hydroxymethylglutaryl-coenzyme A reductase inhibitors
(STATINS)
- Atorvastatin (Lipitor)
- Crestor
- zocor
-
Hydroxymethylglutaryl-coenzyme A reductase inhibitors(STATINS) MOA
decrease liver cholesterol production
-
Hydroxymethylglutaryl-coenzyme A reductase inhibitors(STATINS) use
hyperlipidemia
-
Hydroxymethylglutaryl-coenzyme A reductase inhibitors(STATINS) contras
allergy, pregnancy, liver disease, high liver enzymes
-
Hydroxymethylglutaryl-coenzyme A reductase inhibitors(STATINS) SE
- mild GI, rash, HA, high liver enzymes, myopathy
- (report right away rhabdomyolysis)
-
Hydroxymethylglutaryl-coenzyme A reductase inhibitors(STATINS) Labs
-
Hydroxymethylglutaryl-coenzyme A reductase inhibitors(STATINS) imps
- Check alcohol use
- Check myopathies before and after
- Teach to fast 12-14 hr before lipid panel
- No abrupt d/c
- Check eye problems
-
Rhabdomyloysis
Breakdown of muscle protein accompanied by myogloburia, severe renal strain, acute renal failure, death
-
-
Rhabdomyloysis
soreness, change in urine, fever, malaise, N/V
-
Rhabdomyloysis risks
- Older than 65yo
- Hypothryroidism
- Renal insuffiecency
- Use of cyclosporine, niacin, or erythromycin with
- statin use
-
Cholestryamine (questran)
- Class: Bile acid sequestrants
- MOA: bind bile, preventing reabsorption of bile acids from small intestines
- (bile salts are necessary for absorption of cholelestrol)
-
Cholestryamine (questran) uses
hyperlipoproteinemia
-
Cholestryamine (questran) contras
allergy, bililary/bowel obstruction, PKU
-
Cholestryamine (questran) SE
constipation, heartburn, nausea, belching, bloating, orthostatic hypotension, tinnitus
-
Cholestryamine (questran) Labs
liver, electrolytes
-
Cholestryamine (questran) imps
- Increase fiber and fluids
- Take all other drugs at least 1
- hour prior or 4-6 hr after
- Supplement of fat vitamins (ADEK)
- Mix powder with crushed fruit or 4-6 oz of fluid
- Dissolve completely
- Take just before or with meals
- Change position slowly
- Contact immediately if black tarry stool occurs
-
Furosemide (Lasix)
- Class: loop diuretic
- MOA: block chloride and sodium reabsorption in ascending limb of the loop of henle; also activates prostaglandins, dilating blood vessels, decreases BP, PVR, SVR, CVP
-
Furosemide (Lasix) uses
- great for rapid dieresis; edema and pulmonary edema r/t HF,
- liver/renal disease, control HTN, increase Ca excretion, ascites
-
Furosemide (Lasix) contras
allergy, hepatic coma, severe electrolyte loss
-
Furosemide (Lasix) SE
- hypokalemia, erythema, exfoliative dermatitis,
- phosensitivity, dizzy, HA, tinnitus, blurred vision, hyperglycemia
-
Furosemide (Lasix) interactions
- increase ototoxicity: vanco, chloroquine
- hypokalemia/increase dig toxic: digoxin and corticosteroids
- increase lithium: lithium
- decreased effects: NSAIDS
- hyperglycemia: sulfonylureas
-
Furosemide (Lasix) imps
- k supplement needed
- eat k rich foods (bananas,
- oranges, apricots, dates, raisins, broccoli, potatoes, wheat bread, legumes)
-
s/s of hypokalemia
- weakness, leg cramps, and other cramping of
- muscles
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