STEP 2 Rapid Review Drug Interactions / Reactions

  1. Interaction/Reaction: Induction of P-450 enzymes
    Barbiturates, phenytoin, carbamazepine, rifampin, quinidine, giseofulvin
  2. Interaction/Reaction: Inhibition of P-450 enzymes
    Cimetidine, ketoconazole, INH, grapefruit, erythromycin, sulfonamides
  3. Interaction/Reaction: Metabolism by P-450 enzymes
    Benzos, amide anesthetics, metoprolol, propranolol, nifedipine, phenytoin, quinidine, theophylline, warfarin, barbiturates
  4. Interaction/Reaction: Increased risk of digoxin toxicity
    Quinidine, cimetidine, amiodarone, CCBs
  5. Interaction/Reaction: Competition for albumin-binding sites
    Warfarin, ASA, phenytoin
  6. Interaction/Reaction: Blood dyscrasias
    Ibuprofen, quinidine, methyldopa, chemotherapeutic agents
  7. Interaction/Reaction: Hemolysis in G6PD-deficient patients
    Sulfonamides, INH, ASA, ibuprofen, nitrofurantoin, primaquine, pyrimethamine, chloramphenicol
  8. Interaction/Reaction: Gynecomastia
    Spironolactone, Estrogens, Digitalis, Cimetidine, chronic Alcohol use, Ketoconazole
  9. Interaction/Reaction: SJS
    Ethosuximide, sulfonamides
  10. Interaction/Reaction: Photosensitivity
    Tetracycline, amiodarone, sulfonamides
  11. Interaction/Reaction: Drug-induced SLE
    Procainamide, hydralazine, INH, penicillamine, chlorpromazine, methyldopa, quinidine
Card Set
STEP 2 Rapid Review Drug Interactions / Reactions
emergency med chapter